Prevalence and prognostic value of late gadolinium enhancement on CMR in aortic stenosis: meta-analysis

Objectives The aim of this study was to investigate the prevalence and prognostic value of late gadolinium enhancement (LGE), as assessed by cardiovascular magnetic resonance (CMR) imaging, in patients with aortic stenosis. Methods and results A systematic search of PubMed and EMBASE was performed,...

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Bibliographic Details
Published in:European radiology 2020, Vol.30 (1), p.640-651
Main Authors: Balciunaite, Giedre, Skorniakov, Viktor, Rimkus, Arnas, Zaremba, Tomas, Palionis, Darius, Valeviciene, Nomeda, Aidietis, Audrius, Serpytis, Pranas, Rucinskas, Kestutis, Sogaard, Peter, Glaveckaite, Sigita
Format: Article
Language:English
Subjects:
Aged
Aorta - diagnostic imaging
Aortic stenosis
Aortic Valve Stenosis - diagnostic imaging
Aortic Valve Stenosis - pathology
Cardiac
Cardiovascular diseases
Cohort Studies
Contrast Media - pharmacokinetics
Diagnostic Radiology
Electrocardiography
Female
Fibrosis
Gadolinium
Gadolinium - pharmacokinetics
Health risk assessment
Humans
Image Enhancement - methods
Imaging
Internal Medicine
Interventional Radiology
Magnetic resonance
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medical prognosis
Medicine
Medicine & Public Health
Meta-analysis
Middle Aged
Mortality
Neuroradiology
Observational Studies as Topic
Prevalence
Prognosis
Radiology
Stenosis
Ultrasound
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Summary:Objectives The aim of this study was to investigate the prevalence and prognostic value of late gadolinium enhancement (LGE), as assessed by cardiovascular magnetic resonance (CMR) imaging, in patients with aortic stenosis. Methods and results A systematic search of PubMed and EMBASE was performed, and observational cohort studies that analysed the prevalence of LGE and its relation to clinical outcomes in patients with aortic stenosis were included. Odds ratios were used to measure an effect of the presence of LGE on both all-cause and cardiovascular mortality. Nineteen studies were retrieved, accounting for 2032 patients (mean age 69.8 years, mean follow-up 2.8 years). We found that LGE is highly prevalent in aortic stenosis, affecting half of all patients (49.6%), with a non-infarct pattern being the most frequent type (63.6%). The estimated extent of focal fibrosis, expressed in % of LV mass, was equal to 3.83 (95% CI [2.14, 5.52], p  
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-019-06386-3