Synthesis, Identification, Theoretical Study and effect of Heterocyclic Compounds on the Activity of GOT and GPT Enzymes

• Published in: Research journal of pharmacy and technology 2019, Vol.12 (7), p.3237-3244
• Main Authors: Khudhair, Zahraa T., Al-Tamimi, Entesar O.
• Format: Article
• Language: English
• Subjects: Biochemistry; Enzymes; Ethanol; Kidneys; Metabolism; Physical properties
• ISSN: 0974-3618; 0974-360X; 0974-306X
• DOI: 10.5958/0974-360X.2019.00544.4

The performance of the kidneys is generally tested by observing blood urea nitrogen levels, creatinine clearance and also glomerular filtration rate, the flow rate of purified fluid via the kidney [2]. [...]to urea, creatinine concentrations in body fluids are not influenced by protein consumption, so creatinine levels serve as a more reliable indication of renal function [6]. [...]creatinine quantification is an important research area in science, in particular in the areas of clinical biochemistry, biology and medicine [7,8]. Melting points were measured on Gallen Kamp capillary melting point apparatus and were uncorrected, FT-IR measurements were recorded on Shimadzu model FTIR-8400S. 1HNMR spectra were obtained with Bruker spectrophotometer model ultrashield at 400 MHz in D2O solution with the TMS as internal standard. 2.2.Synthesis of the organic compounds: 2.2.1.Synthesis of compound (1a) [9] Literature procedure was used with modifications. [...]we worked theoretical study For the purpose of comparison with the experimental results, there are good agreement between theoretical and experimental results.