Search for Biologically Active Substances with Antimicrobial and Antifungal Action in the series of 2.5-disubstituted 1, 3, 4-tiadiazoles

• Published in: Research journal of pharmacy and technology 2019, Vol.12 (6), p.2871-2876
• Main Authors: Sych, Igor V., Drapak, Iryna V., Suleiman, Marharyta M., Rakhimova, Maryna V., Kobzar, Natalya P., Sych, Irina A., Perekhoda, Lina O.
• Format: Article
• Language: English
• Subjects: Antifungal agents; Antimicrobial agents; Biological activity; Hydrochloric acid; Laboratories; Microorganisms; Temperature
• ISSN: 0974-3618; 0974-360X; 0974-306X
• DOI: 10.5958/0974-360X.2019.00483.9

Analysis of scientific literature suggests that there is a growing interest in investigation of the mechanism of the N-S bond formation in biological objects, which is owing to the confirmed important role of aromatic sulfonic acid derivatives in inhibition of enzymes. [...]a certain interest in the search for new active substances with antimicrobial and antifungal activity was attributed to compounds, which composition includes a sulfonamide moiety [1-5,18,19]. Tertiary amines are widely used as hydrogen chloride acceptors. [...]in order to obtain target compounds, we have suggested interaction of 2-amino-5-R-1,3,4-thiadiazole with di- and three-substituted aryl sulphonyl chlorides in the pyridine medium, which can at the same time serve as a hydrogen chloride acceptor. According to the WHO recommendations, the assessment of the activity of samples in relation to gram-positive microorganisms was carried out with the reference strain - Staphylococcus aureus ATCC 25922. [...]of studies of six test compounds it was found that they all have sensitivity to both gram-positive and gram-negative bacteria.