Langerhans Cell Histiocytosis in a 5-Year-Old Girl: A Case Report and Review of Literature

Abstract Langerhans cell histiocytosis (LCH) is an uncommon hematological disorder affecting infants and young children. LCH is a rare disorder of the reticuloendothelial system associated with proliferation of Langerhans cells and mature eosinophils. LCH can involve any bone, but the most common ar...

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Bibliographic Details
Published in:Indian journal of medical and paediatric oncology 2019-07, Vol.40 (S 01), p.S176-S180
Main Authors: Rao, Shruthi, Hegde, Shruthi, Thilak, PS Gopinath, Babu, G Subhas, Ajila, Vidya, Shetty, Urvashi, Buch, Sajad Ahmad
Format: Article
Language:English
Subjects:
Age
Antigens
Autoimmune diseases
Bones
Care and treatment
Case reports
Case studies
Chemotherapy
Consent
Diagnosis
Fractures
Histiocytosis
Jaw
Langerhans-cell histiocytosis
Lymphatic system
Pediatric research
Practitioner Section
Young adults
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Summary:Abstract Langerhans cell histiocytosis (LCH) is an uncommon hematological disorder affecting infants and young children. LCH is a rare disorder of the reticuloendothelial system associated with proliferation of Langerhans cells and mature eosinophils. LCH can involve any bone, but the most common are pelvis, ribs, skull, long bones, vertebra, and facial bones. In the skull, frontal and parietal bones are commonly involved followed by the jaws, where mandible is more commonly affected than the maxilla. In this article, we report a case of LCH in a 5-year-old child involving the mandible. Swelling of one side of the face and aggressive periosteal reaction led to the diagnosis of monostotic LCH. The manuscript also summarizes the results of a literature search in PubMed of reported cases of LCH over the past 10 years.
ISSN:0971-5851
0975-2129
DOI:10.4103/ijmpo.ijmpo_258_17