TFAA‐Catalyzed Annulation Synthesis of Spiro Pyrroloquinoxaline Derivatives from 1‐(2‐Aminophenyl)pyrroles and Benzoquinones/Ketones

A metal‐free trifluorosulfonate anhydride (TFAA)‐catalyzed strategy for the synthesis of spiro pyrrolo[1,2‐a]quinoxalines from 1‐(2‐aminophenyl)pyrroles and benzoquinones/ketones has been developed. With this general method, spiro pyrrolo[1,2‐a]quinoxalines have been accessed via nucleophilic additi...

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Bibliographic Details
Published in:Chemistry, an Asian journal an Asian journal, 2019-08, Vol.14 (16), p.2898-2902
Main Authors: Ni, Jixiang, Jiang, Yong, Qi, Zhenjie, Rulong Yan
Format: Article
Language:English
Subjects:
Chemical reactions
Chemical synthesis
Chemistry
Functional groups
Ketones
Pyrroles
Quinoxalines
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Summary:A metal‐free trifluorosulfonate anhydride (TFAA)‐catalyzed strategy for the synthesis of spiro pyrrolo[1,2‐a]quinoxalines from 1‐(2‐aminophenyl)pyrroles and benzoquinones/ketones has been developed. With this general method, spiro pyrrolo[1,2‐a]quinoxalines have been accessed via nucleophilic addition and cyclization. This reaction exhibits good functional group tolerance, and a wide range of products are obtained in moderate to good yields.
ISSN:1861-4728
1861-471X
DOI:10.1002/asia.201900567