Effects of a Gut Microbiome Toxin, p-Cresol, on the Contents of the NMDA2B Receptor Subunit in the Nucl. Accumbens of Rats

The effects of p-cresol on the levels of subunit 2RB of NMDA receptors and also of AMPA and GABAA receptors in the nucl. accumbens (NAc) of rats were studied. As was found, the content of the NR2B subunit of NMDA glutamate receptors is increased in p-cresol-treated rats, and this elevation is abroga...

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Bibliographic Details
Published in:Neurophysiology (New York) 2019-03, Vol.51 (2), p.72-76
Main Authors: Tevzadze, G., Zhuravliova, E., Meparishvili, M., Lortkipanidze, T., Shanshiashvili, L., Kikvidze, Z., Mikeladze, D.
Format: Article
Language:English
Subjects:
Autism
Biomedical and Life Sciences
Biomedicine
Cresol
Digestive system
EDTA
GABA
Glutamate
Glutamatergic transmission
Glutamic acid receptors (ionotropic)
Intestinal microflora
Intranasal administration
Mesolimbic system
Microbiomes
Microbiota
N-Methyl-D-aspartic acid receptors
Naltrexone
Nervous system diseases
Neurological diseases
Neurosciences
Nucleus accumbens
Oxytocin
p-Cresol
α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid
γ-Aminobutyric acid A receptors
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Summary:The effects of p-cresol on the levels of subunit 2RB of NMDA receptors and also of AMPA and GABAA receptors in the nucl. accumbens (NAc) of rats were studied. As was found, the content of the NR2B subunit of NMDA glutamate receptors is increased in p-cresol-treated rats, and this elevation is abrogated after intranasal administration of oxytocin. These effects of oxytocin were partly reversed after i.p. injections of naltrexone. We suggest that interplay between mesolimbic glutamatergic, oxytocinergic, and opioidergic systems in the NAc may be important in the development of p-cresol-dependent neurological disorders.
ISSN:0090-2977
1573-9007
DOI:10.1007/s11062-019-09795-8