Synthesis of Some New Substituted Thieno[2,3-d]pyrimidine Derivatives as Antimicrobial Agents

A series of thieno-pyrimidine derivatives are synthesized from 5′-amino-2,3′-bithiophene-4′-carboxylate via the corresponding intermediate N -benzoylated carboxamide derivatives. The target compounds are tested for antibacterial and antifungal activity. Some of the synthesized compounds demonstrate...

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Bibliographic Details
Published in:Russian journal of general chemistry 2019-07, Vol.89 (7), p.1528-1534
Main Authors: El-Shehry, M. F., Hosni, H. M., Amr, A. E., Ibrahim, A. A., Fayed, Ahmed A., Elnaggar, D. H.
Format: Article
Language:English
Subjects:
Antibacterial materials
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Derivatives
Fungicides
Pyrimidines
Synthesis
Thiophene
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Summary:A series of thieno-pyrimidine derivatives are synthesized from 5′-amino-2,3′-bithiophene-4′-carboxylate via the corresponding intermediate N -benzoylated carboxamide derivatives. The target compounds are tested for antibacterial and antifungal activity. Some of the synthesized compounds demonstrate potent antibacterial activity with LD 50 comparable with the reference drug indomethacin.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363219070247