Salivary Proteomic Analysis of Betel Nut (Areca catechu) Consumers by Mass Spectrometry Revealed Primary Indication of Oral Malignancies

Areca nut is the fourth most widely used addictive and psychoactive substance consumed by approximately 10% of the world’s population. The use of areca nut is estimated to account for up to 50% of oral cancer in the low-income, and middle-income countries. In the present study, the effect of betel n...

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Bibliographic Details
Published in:International journal of peptide research and therapeutics 2020-06, Vol.26 (2), p.1073-1084
Main Authors: Sultan, Rabia, Mirza, Munazza Raza, Choudhary, Muhammad Iqbal, Alam, Mehtab, Haque, Ikram-ul
Format: Article
Language:English
Subjects:
Addicts
Animal Anatomy
Apolipoprotein E
Areca catechu
Biochemistry
Biomedical and Life Sciences
Brain tumors
Chewing
Complement component C3
Consumers
Correlation analysis
Cystatins
DMBT1 protein
Gelatinase B
Health risk assessment
Histology
Ionization
Ions
Life Sciences
Mass spectrometry
Mass spectroscopy
Matrix metalloproteinase
Metalloproteinase
Molecular Medicine
Morphology
Oral cancer
Peptides
Pharmaceutical Sciences/Technology
Pharmacology/Toxicology
Polymer Sciences
Proteins
Proteomics
Saliva
Scientific imaging
Zinc
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Summary:Areca nut is the fourth most widely used addictive and psychoactive substance consumed by approximately 10% of the world’s population. The use of areca nut is estimated to account for up to 50% of oral cancer in the low-income, and middle-income countries. In the present study, the effect of betel nut chewing on saliva proteomics was investigated by using mass spectrometry. Matrix-assisted laser desorption ionization mass spectrometry was used to generate a profile of the peptides in betel nut consumers and control group. We found 13 peptide peaks which were significantly altered ( p  
ISSN:1573-3149
1573-3904
DOI:10.1007/s10989-019-09909-0