Rapid route design of AZD7594

A wide variety of technology platforms were used to rapidly select a commercial manufacturing route to the inhaled glucocorticoid receptor modulator AZD7594. This collaborative approach to the route design employed idea generation, high-throughput salt formation, solubility and chemical reaction scr...

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Bibliographic Details
Published in:Reaction chemistry & engineering 2019-09, Vol.4 (9), p.1658-1673
Main Authors: Carter, Holly L, Connor, Amand W, Hart, Richard, McCabe, James, McIntyre, Allyson C, McMillan, Angus E, Monks, Natalie R, Mullen, Alexander K, Ronson, Thomas O, Steven, Alan, Tomasi, Simone, Yates, Simon D
Format: Article
Language:English
Subjects:
Chemical reactions
Design of experiments
Optimization
Organic chemistry
Route selection
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Summary:A wide variety of technology platforms were used to rapidly select a commercial manufacturing route to the inhaled glucocorticoid receptor modulator AZD7594. This collaborative approach to the route design employed idea generation, high-throughput salt formation, solubility and chemical reaction screening, process analytical techniques and factorial experimental design to propose, assess and select the new strategic route within a five-month window. The selected route is currently undergoing further process development and optimisation and will be implemented in future manufacturing campaigns to supply drug substance for ongoing clinical studies and ultimately for the commercially marketed product. Multidisciplinary collaboration enables the rapid and efficient design and selection of an improved manufacturing route to a new potential medicine for the treatment of asthma.
ISSN:2058-9883
2058-9883
DOI:10.1039/c9re00118b