Serum metabolomics can predict the outcome of first systematic transrectal prostate biopsy in patients with PSA <10 ng/ml

To assess the predictive value of metabolomic analysis for the presence of prostate cancer (PCa) at first systematic biopsy. Ninety serum samples from patients with suspicion for PCa were included. Targeted and nontargeted metabolomic analysis was performed. Six metabolites were combined into a pred...

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Bibliographic Details
Published in:Future oncology (London, England) England), 2017-08, Vol.13 (20), p.1793-1800
Main Authors: Andras, Iulia, Crisan, Nicolae, Vesa, Stefan, Rahota, Razvan, Romanciuc, Florina, Lazar, Andrei, Socaciu, Carmen, Matei, Deliu-Victor, de Cobelli, Ottavio, Bocsan, Ioan-Stelian, Coman, Radu-Tudor
Format: Article
Language:English
Subjects:
Accuracy
Aged
Amino acids
Antigens
Biomarkers
Biopsy
Diagnosis, Differential
Discriminant analysis
Humans
Male
Medical screening
Metabolites
Metabolome
metabolomics
Metabolomics - methods
Middle Aged
Mortality
NMR
Nuclear magnetic resonance
Patients
prediction score
Prognosis
Prostate cancer
Prostate-Specific Antigen - blood
Prostatic Neoplasms - blood
Prostatic Neoplasms - diagnosis
ROC Curve
Software
Systematic review
Ultrasonic imaging
Variables
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Summary:To assess the predictive value of metabolomic analysis for the presence of prostate cancer (PCa) at first systematic biopsy. Ninety serum samples from patients with suspicion for PCa were included. Targeted and nontargeted metabolomic analysis was performed. Six metabolites were combined into a predictive score. A cutoff value of 0.528 for the metabolomic score showed a good accuracy for the prediction of PCa at biopsy (Area under the curve (AUC): 0.779; p < 0.001). These results were validated in a subgroup of patients, showing similar accuracy (p = 0.1). For patients with prostate specific antigen (PSA) less than 10 ng/ml, the score showed a Se 80.95%, Sp 64.52% for the detection of PCa at biopsy. Metabolomic analysis can predict the outcome of the first systematic biopsy.
ISSN:1479-6694
1744-8301
DOI:10.2217/fon-2017-0078