HOXA13 is associated with unfavorable survival and acts as a novel oncogene in prostate carcinoma

To investigate the clinical relevance and functional role of HOXA13 in prostate cancer Methods: PCR, western blot and immunohistochemistry were performed to determine the expression. Kaplan-Meier and Cox regression survival analyses investigated the clinical relevance. Cell viability, flow cytometry...

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Bibliographic Details
Published in:Future oncology (London, England) England), 2017-07, Vol.13 (17), p.1505-1516
Main Authors: Dong, Yan, Cai, Ying, Liu, Bo, Jiao, Xiang, Li, Zhong-Tai, Guo, Da-Yong, Li, Xin-Wei, Wang, Yong-Jun, Yang, Deng-Ke
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Apoptosis - genetics
Biomarkers
Biomarkers, Tumor - genetics
Carcinoma - epidemiology
Carcinoma - genetics
Carcinoma - pathology
Cell Line, Tumor
Cell Proliferation - genetics
Disease-Free Survival
Epigenetics
Esophagus
Gene expression
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Homeodomain Proteins - genetics
Humans
Kaplan-Meier Estimate
Laboratories
Liver cancer
Male
Medical prognosis
Middle Aged
Oncogenes - genetics
Patients
Prognosis
Prostate cancer
Prostatic Neoplasms - epidemiology
Prostatic Neoplasms - genetics
Prostatic Neoplasms - pathology
Thyroid gland
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Summary:To investigate the clinical relevance and functional role of HOXA13 in prostate cancer Methods: PCR, western blot and immunohistochemistry were performed to determine the expression. Kaplan-Meier and Cox regression survival analyses investigated the clinical relevance. Cell viability, flow cytometry and transwell assays were used to determine the functional roles. HOXA13 expression is sharply increased in carcinoma tissues and is significantly associated with poor prognosis of prostate cancer patients. Interestingly, nucleus not cytoplasm HOXA13 expression is associated with unfavorable survival of the patients. Furthermore, nucleus HOXA13 expression represents an unfavorable and independent prognosis factor of histological grade 2 or Gleason grade
ISSN:1479-6694
1744-8301
DOI:10.2217/fon-2016-0522