RESHAPING PURPOSE - USE OF METFORMIN IN ENDOMETRIOSIS AN APPROACH TO RECENT LITERATURE

Sampson's theory regarding the transplantation of endometrial tissue on the pelvic peritoneum via retrograde menstruation is the most widely accepted explanation for the development of pelvic endometriosis12. Since retrograde menstruation is observed in almost all reproductive-aged women underg...

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Published in:Research and science today 2019-01, p.158-171
Main Authors: Iftene, Lavinia, Mehedintu, Claudia, Bratila, Elvira, Frincu, Francesca, Mihai, Diana, Ionescu, Gabriela, Bratu, Ovidiu Gabriel, Socea, Bogdan, Cazachevici, Ana-Maria-Emanuela
Format: Article
Language:English
Subjects:
17β-Estradiol
Adipose tissue
Aromatase
Bleeding
Cell culture
Cytokines
Efflux
Endometriosis
Endometrium
Enzymatic activity
Enzyme activity
Enzymes
Estrogens
Immune clearance
Immune system
Infertility
Insulin
Medical research
Menstruation
Metformin
Pain
Pathogenesis
Peritoneum
Placenta
Polycystic ovary syndrome
Pregnancy
Sex hormones
Stromal cells
Transplantation
Transplants & implants
Womens health
Xenoestrogens
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Summary:Sampson's theory regarding the transplantation of endometrial tissue on the pelvic peritoneum via retrograde menstruation is the most widely accepted explanation for the development of pelvic endometriosis12. Since retrograde menstruation is observed in almost all reproductive-aged women undergoing menstrual bleeding, endometriosis is postulated to develop as a result of the coexistence of a defect in clearance of the menstrual efflux from pelvic peritoneal surfaces, raising questions of the immune system's integrity13. The supposed mechanism of action of metformin in endometriosis is proposed to be a decrease in aromatase enzyme activity and inhibition of proliferation on endometrial glands27. [...]circulating estradiol levels are decreased in response to the increase in SHBG levels, thus reducing and affecting the dynamics of endometrial ectopic tissue28. [...]endometriosis-derived stromal cells in culture incubated with a cAMP analog displayed extraordinarily high levels of aromatase activity comparable to that in placental syncytiotrophoblast35. Mullerian tissues are known targets of estrogen action36. [...]recently, estrogen action has been classically viewed to occur only via an "endocrine" mechanism: in other words, it was thought that only circulating estradiol, whether secreted by the ovary or formed in the adipose tissue, could exert an estrogenic effect after delivery to target tissues via the bloodstream37.
ISSN:2247-4455
2285-9632