The current understanding of immunotoxicity induced by silica nanoparticles

Extracellular media (EMs) containing bacteria and SiNPs synergistically increased cytotoxicity toward and cytokine production of dendritic cells (DCs), which was influenced by the nanoparticle dose and bacterial species. Extracellular media containing Pseudomonas aeruginosa and Staphylococcus aureus...

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Bibliographic Details
Published in:Nanomedicine (London, England) England), 2019-05, Vol.14 (10), p.1227-1229
Main Authors: Liangjiao, Chen, Yiyuan, Kang, Hongbing, Guan, Jia, Liu, Wenchao, Zhong, Yanli, Zhang, Longquan, Shao
Format: Article
Language:English
Subjects:
adjuvants
allergic responses
autophagy
Bacteria
Bacterial infections
Cancer
Cytotoxicity
Dendritic cells
Gene expression
Hemoglobin
Immune system
immunotoxicity
inflammatory cells
Investigations
Lymphocytes
Nanoparticles
phagocytes
ROS production
silica nanoparticles
Silicosis
Tuberculosis
Vaccines
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Summary:Extracellular media (EMs) containing bacteria and SiNPs synergistically increased cytotoxicity toward and cytokine production of dendritic cells (DCs), which was influenced by the nanoparticle dose and bacterial species. Extracellular media containing Pseudomonas aeruginosa and Staphylococcus aureus, which are pathogenic bacteria, induced the production of cytokines only when they were simultaneously mixed with toxic concentrations of SiNPs (7). Cationic silica nanoparticles (CSiNPs) can destroy tumors in vivo and stimulate the immune response when combined with molecular adjuvants, which activates interferon gene stimulators in antigen-presenting cells (10). Mohammadpour R, Yazdimamaghani M, Reilly C, Ghandehari H. Transient receptor potential (TRP) ion channel-dependent toxicity of silica nanoparticles and Poly(amido amine) (PAMAM) dendrimers.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2019-0107