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Attenuation of negative effects of senescence in human skin using an extract from Sphingomonas hydrophobicum: development of new skin care solution
Objective Intrinsic skin ageing is mainly caused by cellular senescence. p16 and p21 are two important tumour suppressor proteins that play essential roles during cell proliferation and ageing through regulating the expression of several genes. Moreover, physical changes between the ages of 55 and 6...
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| Published in: | International journal of cosmetic science 2019-08, Vol.41 (4), p.391-397 |
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| Main Authors: | , , , , , , , , , |
| Format: | Article |
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| cites | cdi_FETCH-LOGICAL-c3534-4176e1053055d88ad59fa3934a7aa1323fff98216546e591b64c5bfad571c13c3 |
| container_end_page | 397 |
| container_issue | 4 |
| container_start_page | 391 |
| container_title | International journal of cosmetic science |
| container_volume | 41 |
| creator | Gervason, S. Napoli, M. Dreux‐Zhiga, A. Lazzarelli, C. Garcier, S. Briand, A. Albouy, M. Thepot, A. Berthon, J. Y. Filaire, E. |
| description | Objective
Intrinsic skin ageing is mainly caused by cellular senescence. p16 and p21 are two important tumour suppressor proteins that play essential roles during cell proliferation and ageing through regulating the expression of several genes. Moreover, physical changes between the ages of 55 and 60 years affect one's physical and disrupt self‐esteem. The cosmetics industry has focused on bioactive substances derived from natural products such as plants, mushrooms and marine algae to counteract the deleterious effect on skin senescence. Besides these products, compounds produced by bacteria may decelerate individual senescence.
Methods
In order to evaluate the potential benefits of bacteria extract over skin ageing, we investigated whether a Sphingomonas hydrophobicum (SH) extract is able to protect our skin against senescence mechanisms. We used an ageing full‐thickness skin equivalent model, which was treated or not with the bacteria extract in a systemic way for 42 days. p21 and p16 and senescence‐associated galactosidase activity were used to detect cellular senescence with immunohistology. Using a psychobiological approach, we evaluated in vivo the effect of SH extract on self‐esteem, isotropy and suppleness.
Results
Sphingomonas extract significantly suppressed senescence associated with β‐galactosidase activation. It also significantly inhibited the expression of cell cycle inhibitors (p21 and p16). At the same time, the bacteria extract has a significant positive impact on the issue by increasing the expression of versican and fibrillin‐1. Significant improvements of self‐esteem were reported after 56 days of SH extract application. These psychological benefits were accompanied by a significant improvement in skin suppleness and isotropy.
Conclusion
Sphingomonas extract delays intrinsic skin ageing process by inhibiting cellular senescence, and has also the capability to restructure the skin. These beneficial physiological effects induced by SH extract have a positive influence on self‐esteem. Because skin ageing causes emotional distress, SH extract can serve as an anti‐ageing cosmeceutical agent and help to build a better psychological health, and help individuals to assume ageing.
Résumé
Objectif
Le vieillissement intrinsèque de la peau est principalement causé par la sénescence cellulaire. p16 et p21 sont deux importantes protéines suppressives de tumeurs qui jouent un rôle essentiel dans la prolifération et le vieillissement cellulaire en rég |
| doi_str_mv | 10.1111/ics.12534 |
| format | article |
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Intrinsic skin ageing is mainly caused by cellular senescence. p16 and p21 are two important tumour suppressor proteins that play essential roles during cell proliferation and ageing through regulating the expression of several genes. Moreover, physical changes between the ages of 55 and 60 years affect one's physical and disrupt self‐esteem. The cosmetics industry has focused on bioactive substances derived from natural products such as plants, mushrooms and marine algae to counteract the deleterious effect on skin senescence. Besides these products, compounds produced by bacteria may decelerate individual senescence.
Methods
In order to evaluate the potential benefits of bacteria extract over skin ageing, we investigated whether a Sphingomonas hydrophobicum (SH) extract is able to protect our skin against senescence mechanisms. We used an ageing full‐thickness skin equivalent model, which was treated or not with the bacteria extract in a systemic way for 42 days. p21 and p16 and senescence‐associated galactosidase activity were used to detect cellular senescence with immunohistology. Using a psychobiological approach, we evaluated in vivo the effect of SH extract on self‐esteem, isotropy and suppleness.
Results
Sphingomonas extract significantly suppressed senescence associated with β‐galactosidase activation. It also significantly inhibited the expression of cell cycle inhibitors (p21 and p16). At the same time, the bacteria extract has a significant positive impact on the issue by increasing the expression of versican and fibrillin‐1. Significant improvements of self‐esteem were reported after 56 days of SH extract application. These psychological benefits were accompanied by a significant improvement in skin suppleness and isotropy.
Conclusion
Sphingomonas extract delays intrinsic skin ageing process by inhibiting cellular senescence, and has also the capability to restructure the skin. These beneficial physiological effects induced by SH extract have a positive influence on self‐esteem. Because skin ageing causes emotional distress, SH extract can serve as an anti‐ageing cosmeceutical agent and help to build a better psychological health, and help individuals to assume ageing.
Résumé
Objectif
Le vieillissement intrinsèque de la peau est principalement causé par la sénescence cellulaire. p16 et p21 sont deux importantes protéines suppressives de tumeurs qui jouent un rôle essentiel dans la prolifération et le vieillissement cellulaire en régulant l'expression de plusieurs gènes. De plus, les changements physiques survenant entre 55 et 60 ans affectent le physique et perturbent l'estime de soi. L'industrie cosmétique s'est concentrée sur les substances bioactives dérivées de produits naturels tels que les plantes, les champignons et les algues marines pour contrer les effets délétères sur la sénescence de la peau. En plus de ces produits, les composés produits par les bactéries peuvent ralentir la sénescence individuelle.
MÉthodes
Afin d’évaluer les bénéfices potentiels de l'extrait de bactérie sur le vieillissement cutané, nous avons étudié si un extrait de Sphingomonas hydrophobicum (SH) est capable de protéger notre peau des mécanismes de sénescence. Nous avons utilisé un modèle équivalent de peau vieillissante de pleine épaisseur, qui a été traitée ou non avec l'extrait de bactérie de façon systémique pendant 42 jours. p21 et p16, et l'activité galactosidase associée à la sénescence ont été utilisés pour détecter la sénescence cellulaire par immunohistologie. En utilisant une approche psychobiologique, nous avons évalué in vivo l'effet de l'extrait de SH sur l'estime de soi, l'isotropie et la souplesse.
RÉsultats
L'extrait de Sphingomonas a considérablement supprimé la sénescence associée à l'activation de β‐galactosidase. Il a également inhibé de manière significative l'expression des inhibiteurs du cycle cellulaire (p21 et p16). En même temps, l'extrait de bactérie a un impact positif significatif sur le problème en augmentant l'expression du versican et de la fibrilline‐1. Des améliorations significatives de l'estime de soi ont été rapportées après 56 jours d'application de l'extrait de SH. Ces bienfaits psychologiques s'accompagnaient d'une amélioration significative de la souplesse et de l'isotropie de la peau.
Conclusion
L'extrait de Sphingomonas retarde le processus de vieillissement intrinsèque de la peau en inhibant la sénescence cellulaire et a également la capacité de restructurer la peau. Ces effets physiologiques bénéfiques induits par l'extrait de SH ont une influence positive sur l'estime de soi. Parce que le vieillissement de la peau provoque une détresse émotionnelle, l'extrait de SH peut servir d'agent cosméceutique anti‐âge et aider à construire une meilleure santé psychologique, ainsi qu'aider les individus à assumer le vieillissement.
Using a physiological approach, we investigated whether bacteria extract can have a beneficial effect of skin senescence markers. Our results show that Sphingomonas extract may have potential therapeutic properties for treating skin ageing, suggesting unique properties of proteobacteria for future investigations on topical applications.</description><identifier>ISSN: 0142-5463</identifier><identifier>EISSN: 1468-2494</identifier><identifier>DOI: 10.1111/ics.12534</identifier><identifier>PMID: 31032993</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Activation ; Aged ; ageing ; Aging ; Aging (natural) ; Algae ; Attenuation ; Bacteria ; Biological activity ; Cell cycle ; Cell proliferation ; Cosmeceuticals ; Cosmetics ; Cosmetics industry ; Cyclin-dependent kinase inhibitor p21 ; Deceleration ; Fibrillin ; Galactosidase ; Gene expression ; Humans ; Inhibition (psychology) ; Isotropy ; Marine plants ; Middle Aged ; Mushrooms ; Natural products ; Physiological effects ; Placebos ; Plants (botany) ; psychobiology ; self‐esteem ; Senescence ; Skin ; Skin Aging - drug effects ; Skin Care - methods ; Sphingomonas ; Sphingomonas - chemistry ; Tumors ; Versican ; β-Galactosidase</subject><ispartof>International journal of cosmetic science, 2019-08, Vol.41 (4), p.391-397</ispartof><rights>2019 Society of Cosmetic Scientists and the Société Française de Cosmétologie</rights><rights>2019 Society of Cosmetic Scientists and the Société Française de Cosmétologie.</rights><rights>Copyright © 2019 Society of Cosmetic Scientists and the Société Française de Cosmétologie</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3534-4176e1053055d88ad59fa3934a7aa1323fff98216546e591b64c5bfad571c13c3</citedby><cites>FETCH-LOGICAL-c3534-4176e1053055d88ad59fa3934a7aa1323fff98216546e591b64c5bfad571c13c3</cites><orcidid>0000-0002-5127-7486</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31032993$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gervason, S.</creatorcontrib><creatorcontrib>Napoli, M.</creatorcontrib><creatorcontrib>Dreux‐Zhiga, A.</creatorcontrib><creatorcontrib>Lazzarelli, C.</creatorcontrib><creatorcontrib>Garcier, S.</creatorcontrib><creatorcontrib>Briand, A.</creatorcontrib><creatorcontrib>Albouy, M.</creatorcontrib><creatorcontrib>Thepot, A.</creatorcontrib><creatorcontrib>Berthon, J. Y.</creatorcontrib><creatorcontrib>Filaire, E.</creatorcontrib><title>Attenuation of negative effects of senescence in human skin using an extract from Sphingomonas hydrophobicum: development of new skin care solution</title><title>International journal of cosmetic science</title><addtitle>Int J Cosmet Sci</addtitle><description>Objective
Intrinsic skin ageing is mainly caused by cellular senescence. p16 and p21 are two important tumour suppressor proteins that play essential roles during cell proliferation and ageing through regulating the expression of several genes. Moreover, physical changes between the ages of 55 and 60 years affect one's physical and disrupt self‐esteem. The cosmetics industry has focused on bioactive substances derived from natural products such as plants, mushrooms and marine algae to counteract the deleterious effect on skin senescence. Besides these products, compounds produced by bacteria may decelerate individual senescence.
Methods
In order to evaluate the potential benefits of bacteria extract over skin ageing, we investigated whether a Sphingomonas hydrophobicum (SH) extract is able to protect our skin against senescence mechanisms. We used an ageing full‐thickness skin equivalent model, which was treated or not with the bacteria extract in a systemic way for 42 days. p21 and p16 and senescence‐associated galactosidase activity were used to detect cellular senescence with immunohistology. Using a psychobiological approach, we evaluated in vivo the effect of SH extract on self‐esteem, isotropy and suppleness.
Results
Sphingomonas extract significantly suppressed senescence associated with β‐galactosidase activation. It also significantly inhibited the expression of cell cycle inhibitors (p21 and p16). At the same time, the bacteria extract has a significant positive impact on the issue by increasing the expression of versican and fibrillin‐1. Significant improvements of self‐esteem were reported after 56 days of SH extract application. These psychological benefits were accompanied by a significant improvement in skin suppleness and isotropy.
Conclusion
Sphingomonas extract delays intrinsic skin ageing process by inhibiting cellular senescence, and has also the capability to restructure the skin. These beneficial physiological effects induced by SH extract have a positive influence on self‐esteem. Because skin ageing causes emotional distress, SH extract can serve as an anti‐ageing cosmeceutical agent and help to build a better psychological health, and help individuals to assume ageing.
Résumé
Objectif
Le vieillissement intrinsèque de la peau est principalement causé par la sénescence cellulaire. p16 et p21 sont deux importantes protéines suppressives de tumeurs qui jouent un rôle essentiel dans la prolifération et le vieillissement cellulaire en régulant l'expression de plusieurs gènes. De plus, les changements physiques survenant entre 55 et 60 ans affectent le physique et perturbent l'estime de soi. L'industrie cosmétique s'est concentrée sur les substances bioactives dérivées de produits naturels tels que les plantes, les champignons et les algues marines pour contrer les effets délétères sur la sénescence de la peau. En plus de ces produits, les composés produits par les bactéries peuvent ralentir la sénescence individuelle.
MÉthodes
Afin d’évaluer les bénéfices potentiels de l'extrait de bactérie sur le vieillissement cutané, nous avons étudié si un extrait de Sphingomonas hydrophobicum (SH) est capable de protéger notre peau des mécanismes de sénescence. Nous avons utilisé un modèle équivalent de peau vieillissante de pleine épaisseur, qui a été traitée ou non avec l'extrait de bactérie de façon systémique pendant 42 jours. p21 et p16, et l'activité galactosidase associée à la sénescence ont été utilisés pour détecter la sénescence cellulaire par immunohistologie. En utilisant une approche psychobiologique, nous avons évalué in vivo l'effet de l'extrait de SH sur l'estime de soi, l'isotropie et la souplesse.
RÉsultats
L'extrait de Sphingomonas a considérablement supprimé la sénescence associée à l'activation de β‐galactosidase. Il a également inhibé de manière significative l'expression des inhibiteurs du cycle cellulaire (p21 et p16). En même temps, l'extrait de bactérie a un impact positif significatif sur le problème en augmentant l'expression du versican et de la fibrilline‐1. Des améliorations significatives de l'estime de soi ont été rapportées après 56 jours d'application de l'extrait de SH. Ces bienfaits psychologiques s'accompagnaient d'une amélioration significative de la souplesse et de l'isotropie de la peau.
Conclusion
L'extrait de Sphingomonas retarde le processus de vieillissement intrinsèque de la peau en inhibant la sénescence cellulaire et a également la capacité de restructurer la peau. Ces effets physiologiques bénéfiques induits par l'extrait de SH ont une influence positive sur l'estime de soi. Parce que le vieillissement de la peau provoque une détresse émotionnelle, l'extrait de SH peut servir d'agent cosméceutique anti‐âge et aider à construire une meilleure santé psychologique, ainsi qu'aider les individus à assumer le vieillissement.
Using a physiological approach, we investigated whether bacteria extract can have a beneficial effect of skin senescence markers. Our results show that Sphingomonas extract may have potential therapeutic properties for treating skin ageing, suggesting unique properties of proteobacteria for future investigations on topical applications.</description><subject>Activation</subject><subject>Aged</subject><subject>ageing</subject><subject>Aging</subject><subject>Aging (natural)</subject><subject>Algae</subject><subject>Attenuation</subject><subject>Bacteria</subject><subject>Biological activity</subject><subject>Cell cycle</subject><subject>Cell proliferation</subject><subject>Cosmeceuticals</subject><subject>Cosmetics</subject><subject>Cosmetics industry</subject><subject>Cyclin-dependent kinase inhibitor p21</subject><subject>Deceleration</subject><subject>Fibrillin</subject><subject>Galactosidase</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Inhibition (psychology)</subject><subject>Isotropy</subject><subject>Marine plants</subject><subject>Middle Aged</subject><subject>Mushrooms</subject><subject>Natural products</subject><subject>Physiological effects</subject><subject>Placebos</subject><subject>Plants (botany)</subject><subject>psychobiology</subject><subject>self‐esteem</subject><subject>Senescence</subject><subject>Skin</subject><subject>Skin Aging - drug effects</subject><subject>Skin Care - methods</subject><subject>Sphingomonas</subject><subject>Sphingomonas - chemistry</subject><subject>Tumors</subject><subject>Versican</subject><subject>β-Galactosidase</subject><issn>0142-5463</issn><issn>1468-2494</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kMlOwzAQhi0EgrIceAFkiROHgNcs3KqKpVIlDsA5cp0xDTR2sJOWPgcvjEuAG754PPr0zfhH6JSSSxrPVa3DJWWSix00oiLNEyYKsYtGhAqWSJHyA3QYwishRBQ530cHnBLOioKP0Oe468D2qqudxc5gCy-xXgEGY0B3YdsLYCFosBpwbfGib5TF4S2WfajtC44v-Oi80h023jX4sV3EtmucVQEvNpV37cLNa90317iCFSxd24DthmnrwaSVBxzcst_ucYz2jFoGOPm5j9Dz7c3T5D6ZPdxNJ-NZonn8ayJolgIlkhMpqzxXlSyM4gUXKlOKcsaNMUXOaBoTAFnQeSq0nJvIZVRTrvkROh-8rXfvPYSufHW9t3FkyViWsZznuYzUxUBp70LwYMrW143ym5KScht_GeMvv-OP7NmPsZ83UP2Rv3lH4GoA1vUSNv-byunkcVB-Af9PkQw</recordid><startdate>201908</startdate><enddate>201908</enddate><creator>Gervason, S.</creator><creator>Napoli, M.</creator><creator>Dreux‐Zhiga, A.</creator><creator>Lazzarelli, C.</creator><creator>Garcier, S.</creator><creator>Briand, A.</creator><creator>Albouy, M.</creator><creator>Thepot, A.</creator><creator>Berthon, J. Y.</creator><creator>Filaire, E.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0002-5127-7486</orcidid></search><sort><creationdate>201908</creationdate><title>Attenuation of negative effects of senescence in human skin using an extract from Sphingomonas hydrophobicum: development of new skin care solution</title><author>Gervason, S. ; Napoli, M. ; Dreux‐Zhiga, A. ; Lazzarelli, C. ; Garcier, S. ; Briand, A. ; Albouy, M. ; Thepot, A. ; Berthon, J. Y. ; Filaire, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3534-4176e1053055d88ad59fa3934a7aa1323fff98216546e591b64c5bfad571c13c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Activation</topic><topic>Aged</topic><topic>ageing</topic><topic>Aging</topic><topic>Aging (natural)</topic><topic>Algae</topic><topic>Attenuation</topic><topic>Bacteria</topic><topic>Biological activity</topic><topic>Cell cycle</topic><topic>Cell proliferation</topic><topic>Cosmeceuticals</topic><topic>Cosmetics</topic><topic>Cosmetics industry</topic><topic>Cyclin-dependent kinase inhibitor p21</topic><topic>Deceleration</topic><topic>Fibrillin</topic><topic>Galactosidase</topic><topic>Gene expression</topic><topic>Humans</topic><topic>Inhibition (psychology)</topic><topic>Isotropy</topic><topic>Marine plants</topic><topic>Middle Aged</topic><topic>Mushrooms</topic><topic>Natural products</topic><topic>Physiological effects</topic><topic>Placebos</topic><topic>Plants (botany)</topic><topic>psychobiology</topic><topic>self‐esteem</topic><topic>Senescence</topic><topic>Skin</topic><topic>Skin Aging - drug effects</topic><topic>Skin Care - methods</topic><topic>Sphingomonas</topic><topic>Sphingomonas - chemistry</topic><topic>Tumors</topic><topic>Versican</topic><topic>β-Galactosidase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gervason, S.</creatorcontrib><creatorcontrib>Napoli, M.</creatorcontrib><creatorcontrib>Dreux‐Zhiga, A.</creatorcontrib><creatorcontrib>Lazzarelli, C.</creatorcontrib><creatorcontrib>Garcier, S.</creatorcontrib><creatorcontrib>Briand, A.</creatorcontrib><creatorcontrib>Albouy, M.</creatorcontrib><creatorcontrib>Thepot, A.</creatorcontrib><creatorcontrib>Berthon, J. Y.</creatorcontrib><creatorcontrib>Filaire, E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>International journal of cosmetic science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gervason, S.</au><au>Napoli, M.</au><au>Dreux‐Zhiga, A.</au><au>Lazzarelli, C.</au><au>Garcier, S.</au><au>Briand, A.</au><au>Albouy, M.</au><au>Thepot, A.</au><au>Berthon, J. Y.</au><au>Filaire, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Attenuation of negative effects of senescence in human skin using an extract from Sphingomonas hydrophobicum: development of new skin care solution</atitle><jtitle>International journal of cosmetic science</jtitle><addtitle>Int J Cosmet Sci</addtitle><date>2019-08</date><risdate>2019</risdate><volume>41</volume><issue>4</issue><spage>391</spage><epage>397</epage><pages>391-397</pages><issn>0142-5463</issn><eissn>1468-2494</eissn><abstract>Objective
Intrinsic skin ageing is mainly caused by cellular senescence. p16 and p21 are two important tumour suppressor proteins that play essential roles during cell proliferation and ageing through regulating the expression of several genes. Moreover, physical changes between the ages of 55 and 60 years affect one's physical and disrupt self‐esteem. The cosmetics industry has focused on bioactive substances derived from natural products such as plants, mushrooms and marine algae to counteract the deleterious effect on skin senescence. Besides these products, compounds produced by bacteria may decelerate individual senescence.
Methods
In order to evaluate the potential benefits of bacteria extract over skin ageing, we investigated whether a Sphingomonas hydrophobicum (SH) extract is able to protect our skin against senescence mechanisms. We used an ageing full‐thickness skin equivalent model, which was treated or not with the bacteria extract in a systemic way for 42 days. p21 and p16 and senescence‐associated galactosidase activity were used to detect cellular senescence with immunohistology. Using a psychobiological approach, we evaluated in vivo the effect of SH extract on self‐esteem, isotropy and suppleness.
Results
Sphingomonas extract significantly suppressed senescence associated with β‐galactosidase activation. It also significantly inhibited the expression of cell cycle inhibitors (p21 and p16). At the same time, the bacteria extract has a significant positive impact on the issue by increasing the expression of versican and fibrillin‐1. Significant improvements of self‐esteem were reported after 56 days of SH extract application. These psychological benefits were accompanied by a significant improvement in skin suppleness and isotropy.
Conclusion
Sphingomonas extract delays intrinsic skin ageing process by inhibiting cellular senescence, and has also the capability to restructure the skin. These beneficial physiological effects induced by SH extract have a positive influence on self‐esteem. Because skin ageing causes emotional distress, SH extract can serve as an anti‐ageing cosmeceutical agent and help to build a better psychological health, and help individuals to assume ageing.
Résumé
Objectif
Le vieillissement intrinsèque de la peau est principalement causé par la sénescence cellulaire. p16 et p21 sont deux importantes protéines suppressives de tumeurs qui jouent un rôle essentiel dans la prolifération et le vieillissement cellulaire en régulant l'expression de plusieurs gènes. De plus, les changements physiques survenant entre 55 et 60 ans affectent le physique et perturbent l'estime de soi. L'industrie cosmétique s'est concentrée sur les substances bioactives dérivées de produits naturels tels que les plantes, les champignons et les algues marines pour contrer les effets délétères sur la sénescence de la peau. En plus de ces produits, les composés produits par les bactéries peuvent ralentir la sénescence individuelle.
MÉthodes
Afin d’évaluer les bénéfices potentiels de l'extrait de bactérie sur le vieillissement cutané, nous avons étudié si un extrait de Sphingomonas hydrophobicum (SH) est capable de protéger notre peau des mécanismes de sénescence. Nous avons utilisé un modèle équivalent de peau vieillissante de pleine épaisseur, qui a été traitée ou non avec l'extrait de bactérie de façon systémique pendant 42 jours. p21 et p16, et l'activité galactosidase associée à la sénescence ont été utilisés pour détecter la sénescence cellulaire par immunohistologie. En utilisant une approche psychobiologique, nous avons évalué in vivo l'effet de l'extrait de SH sur l'estime de soi, l'isotropie et la souplesse.
RÉsultats
L'extrait de Sphingomonas a considérablement supprimé la sénescence associée à l'activation de β‐galactosidase. Il a également inhibé de manière significative l'expression des inhibiteurs du cycle cellulaire (p21 et p16). En même temps, l'extrait de bactérie a un impact positif significatif sur le problème en augmentant l'expression du versican et de la fibrilline‐1. Des améliorations significatives de l'estime de soi ont été rapportées après 56 jours d'application de l'extrait de SH. Ces bienfaits psychologiques s'accompagnaient d'une amélioration significative de la souplesse et de l'isotropie de la peau.
Conclusion
L'extrait de Sphingomonas retarde le processus de vieillissement intrinsèque de la peau en inhibant la sénescence cellulaire et a également la capacité de restructurer la peau. Ces effets physiologiques bénéfiques induits par l'extrait de SH ont une influence positive sur l'estime de soi. Parce que le vieillissement de la peau provoque une détresse émotionnelle, l'extrait de SH peut servir d'agent cosméceutique anti‐âge et aider à construire une meilleure santé psychologique, ainsi qu'aider les individus à assumer le vieillissement.
Using a physiological approach, we investigated whether bacteria extract can have a beneficial effect of skin senescence markers. Our results show that Sphingomonas extract may have potential therapeutic properties for treating skin ageing, suggesting unique properties of proteobacteria for future investigations on topical applications.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31032993</pmid><doi>10.1111/ics.12534</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-5127-7486</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0142-5463 |
| ispartof | International journal of cosmetic science, 2019-08, Vol.41 (4), p.391-397 |
| issn | 0142-5463 1468-2494 |
| language | eng |
| recordid | cdi_proquest_journals_2277283885 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Activation Aged ageing Aging Aging (natural) Algae Attenuation Bacteria Biological activity Cell cycle Cell proliferation Cosmeceuticals Cosmetics Cosmetics industry Cyclin-dependent kinase inhibitor p21 Deceleration Fibrillin Galactosidase Gene expression Humans Inhibition (psychology) Isotropy Marine plants Middle Aged Mushrooms Natural products Physiological effects Placebos Plants (botany) psychobiology self‐esteem Senescence Skin Skin Aging - drug effects Skin Care - methods Sphingomonas Sphingomonas - chemistry Tumors Versican β-Galactosidase |
| title | Attenuation of negative effects of senescence in human skin using an extract from Sphingomonas hydrophobicum: development of new skin care solution |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T18%3A45%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Attenuation%20of%20negative%20effects%20of%20senescence%20in%20human%20skin%20using%20an%20extract%20from%20Sphingomonas%20hydrophobicum:%20development%20of%20new%20skin%20care%20solution&rft.jtitle=International%20journal%20of%20cosmetic%20science&rft.au=Gervason,%20S.&rft.date=2019-08&rft.volume=41&rft.issue=4&rft.spage=391&rft.epage=397&rft.pages=391-397&rft.issn=0142-5463&rft.eissn=1468-2494&rft_id=info:doi/10.1111/ics.12534&rft_dat=%3Cproquest_cross%3E2277283885%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3534-4176e1053055d88ad59fa3934a7aa1323fff98216546e591b64c5bfad571c13c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2277283885&rft_id=info:pmid/31032993&rfr_iscdi=true |