MicroRNA-26a: An Emerging Regulator of Renal Biology and Disease

MicroRNAs (miRNAs) are short, single-stranded, noncoding RNAs that modulate many key biological processes by simultaneously suppressing multiple target genes. Among them, miR-26a, a conserved miRNA among vertebrates, is highly expressed in various tissues. Accumulating evidence demonstrates that miR...

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Published in:Kidney & blood pressure research 2019-06, Vol.44 (3), p.287-297
Main Authors: Li, Xiaoyan, Pan, Xiao, Fu, Xianghui, Yang, Yi, Chen, Jianghua, Lin, Weiqiang
Format: Article
Language:English
Subjects:
Actin
Animals
Apoptosis
Arthritis
Autoimmune diseases
Autophagy
Bioaccumulation
Biological activity
Biology
Cancer
Cell cycle
Cell differentiation
Cell growth
Chromosomes
Cytoskeleton
Diabetes
Diabetes mellitus
Differentiation (biology)
Gene expression
Genomes
Homeostasis
Humans
Immunoregulation
Ischemia
Kidney - physiology
Kidney disease
Kidney diseases
Kidney Diseases - pathology
Kinases
Lymphocytes
Lymphocytes T
Mesangial cell
Mesangial Cells
Metabolic disorders
Metabolism
Metastases
MicroRNAs
MicroRNAs - physiology
miR-26a
miRNA
Phase transitions
Podocyte
Podocytes
Proteins
Regulatory T cell
Reperfusion
Review Article
Ribonucleic acid
RNA
RNA polymerase
Roles
T-Lymphocytes, Regulatory
Vertebrates
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description MicroRNAs (miRNAs) are short, single-stranded, noncoding RNAs that modulate many key biological processes by simultaneously suppressing multiple target genes. Among them, miR-26a, a conserved miRNA among vertebrates, is highly expressed in various tissues. Accumulating evidence demonstrates that miR-26a plays pivotal roles in cellular differentiation, cell growth, apoptosis, and metastasis, thereby participating in the initiation and development of various human diseases, such as metabolic disease and cancer. More recently, miR-26a was found as a versatile regulator of renal biology and disease. miR-26a is intensively involved in the maintenance of podocyte homeostasis and the actin cytoskeleton. It is also able to modulate the homeostasis and function of mesangial cells. In addition, miR-26a affects the expansion of regulatory T cells in the context of ischemia-reperfusion injury and autoimmune diabetes and thus protects the renal system from immune attack. These available data strongly suggest that renal miR-26a possesses critical pathological functions and represents a potential target for renal disease therapies. This review summarizes current knowledge of miR-26a in renal biology and disease, laying the foundation for exploring its previously unknown functions and mechanisms in the renal system.
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Karger AG</publisher><subject>Actin ; Animals ; Apoptosis ; Arthritis ; Autoimmune diseases ; Autophagy ; Bioaccumulation ; Biological activity ; Biology ; Cancer ; Cell cycle ; Cell differentiation ; Cell growth ; Chromosomes ; Cytoskeleton ; Diabetes ; Diabetes mellitus ; Differentiation (biology) ; Gene expression ; Genomes ; Homeostasis ; Humans ; Immunoregulation ; Ischemia ; Kidney - physiology ; Kidney disease ; Kidney diseases ; Kidney Diseases - pathology ; Kinases ; Lymphocytes ; Lymphocytes T ; Mesangial cell ; Mesangial Cells ; Metabolic disorders ; Metabolism ; Metastases ; MicroRNAs ; MicroRNAs - physiology ; miR-26a ; miRNA ; Phase transitions ; Podocyte ; Podocytes ; Proteins ; Regulatory T cell ; Reperfusion ; Review Article ; Ribonucleic acid ; RNA ; RNA polymerase ; Roles ; T-Lymphocytes, Regulatory ; Vertebrates</subject><ispartof>Kidney &amp; blood pressure research, 2019-06, Vol.44 (3), p.287-297</ispartof><rights>2019 The Author(s) Published by S. 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subjects Actin
Animals
Apoptosis
Arthritis
Autoimmune diseases
Autophagy
Bioaccumulation
Biological activity
Biology
Cancer
Cell cycle
Cell differentiation
Cell growth
Chromosomes
Cytoskeleton
Diabetes
Diabetes mellitus
Differentiation (biology)
Gene expression
Genomes
Homeostasis
Humans
Immunoregulation
Ischemia
Kidney - physiology
Kidney disease
Kidney diseases
Kidney Diseases - pathology
Kinases
Lymphocytes
Lymphocytes T
Mesangial cell
Mesangial Cells
Metabolic disorders
Metabolism
Metastases
MicroRNAs
MicroRNAs - physiology
miR-26a
miRNA
Phase transitions
Podocyte
Podocytes
Proteins
Regulatory T cell
Reperfusion
Review Article
Ribonucleic acid
RNA
RNA polymerase
Roles
T-Lymphocytes, Regulatory
Vertebrates
title MicroRNA-26a: An Emerging Regulator of Renal Biology and Disease
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