Fluorinated 1,3-benzothiazin-4-ones containing fluoroquinolone fragment

We have developed an efficient synthetic approach to potential antibacterial agents with double mechanism of action through the combination of antibacterial fluoroquinolones with 1,3-benzothiazin-4-ones.

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2019-06, Vol.55 (6), p.578-582
Main Authors: Nosova, Emiliya V., Batanova, Olga A., Mochulskaya, Nataliya N., Charushin, Valery N.
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Chemistry
Chemistry and Materials Science
Fluorination
Organic Chemistry
Pharmacy
Rifamycins
Tetracycline
Tetracyclines
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Description
Summary:We have developed an efficient synthetic approach to potential antibacterial agents with double mechanism of action through the combination of antibacterial fluoroquinolones with 1,3-benzothiazin-4-ones.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-019-02499-1