Hepatocellular carcinoma and focal hepatic glycogenosis after prolonged azathioprine therapy

A 22-year-old woman without predisposing liver disease developed focal hepatic glycogenosis and hepatocellular carcinoma after 6 years of azathioprine therapy for Crohn's disease. Hepatocellular carcinoma without cirrhosis has previously been described during immunosuppression, but this is the...

Full description

Saved in:
Bibliographic Details
Published in:Human pathology 2000-07, Vol.31 (7), p.874-876
Main Authors: Cattan, St[eacute]phane, Wendum, Dominique, Chazouilleres, Olivier, Schmitz, Jacques, Gendre, Jean-Pierre
Format: Article
Language:English
Subjects:
Adult
Azathioprine - adverse effects
Azathioprine - therapeutic use
Biological and medical sciences
Carcinoma, Hepatocellular - chemically induced
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - surgery
Crohn Disease - drug therapy
Crohn's disease
Drug toxicity and drugs side effects treatment
Female
Glycogen - metabolism
Humans
Immunosuppressive Agents - adverse effects
Immunosuppressive Agents - therapeutic use
Liver - metabolism
Liver cancer
Liver cirrhosis
Liver Neoplasms - chemically induced
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Liver Transplantation
Medical sciences
Pharmacology. Drug treatments
Toxicity: digestive system
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A 22-year-old woman without predisposing liver disease developed focal hepatic glycogenosis and hepatocellular carcinoma after 6 years of azathioprine therapy for Crohn's disease. Hepatocellular carcinoma without cirrhosis has previously been described during immunosuppression, but this is the first report of disseminated focal hepatic glycogenosis after long-term azathioprine therapy. HUM PATHOL 31:874-876.
ISSN:0046-8177
1532-8392
DOI:10.1053/hupa.2000.7629