Ultrafine Nanoparticles of Poly(Methyl Methacrylate-co-Methacrylic Acid) Loaded with Aspirin

Nanoparticles of the poly(methyl methacrylate-co-methacrylic acid) or copolymer of P(MMA-co-MAA), were prepared by semicontinuous heterophase polymerization; they show a mean diameter of 12 nm and a 1.75 MMA/MAA molar ratio determined by carbon-13 nuclear magnetic resonance. The content of MAA, grea...

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Bibliographic Details
Published in:Journal of nanomaterials 2019, Vol.2019 (2019), p.1-9
Main Authors: López, Raúl G., Saade, Hened, Díaz de León Gómez, Ramón Enrique, Valdez-Garza, Janett, Morales, G., Treviño, M. E., López-Muñoz, R., Enríquez-Medrano, Francisco Javier
Format: Article
Language:English
Subjects:
Acetylsalicylic acid
Acids
Aspirin
Biocompatibility
Carbon 13
Chemical industry
Copolymers
Emulsion polymerization
FDA approval
Fourier transforms
Handbooks
Immunology
Methacrylic acid
Nanomaterials
Nanoparticles
NMR
Nuclear magnetic resonance
Pharmaceutical sciences
Polymers
Polymethyl methacrylate
Surface stability
Surfactants
Tablets
Ultrafines
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Summary:Nanoparticles of the poly(methyl methacrylate-co-methacrylic acid) or copolymer of P(MMA-co-MAA), were prepared by semicontinuous heterophase polymerization; they show a mean diameter of 12 nm and a 1.75 MMA/MAA molar ratio determined by carbon-13 nuclear magnetic resonance. The content of MAA, greater than that of Eudragit S100, copolymer of P(MMA-co-MAA) accepted by the FDA for the preparation of tablets, ensures its biocompatibility and its metabolism without toxic effects. Loaded with up to 22 wt. % aspirin, that is, acetylsalicylic acid (ASA), these nanoparticles increase slightly their size, according to transmission electron microscopy; however, the presence of ASA on the nanoparticle surface decreases their stability, which leads to a certain aggregation of the particles in the dispersion. Fourier transform infrared spectrometry was used for demonstrating the loading of ASA in the nanoparticles.
ISSN:1687-4110
1687-4129
DOI:10.1155/2019/3059098