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INTERVENTRICULAR DYSSYNCHRONY DURING CONTINUOUS-FLOW LEFT VENTRICULAR ASSIST DEVICE SUPPORT
We focused on the interventricular dyssynchrony caused by the shortened systole of left ventricle (LV) compared to right ventricle (RV) during left ventricular assist device (LVAD) support. The purpose of this study was to assess and quantify the mechanical interventricular dyssynchorny according to...
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Published in: | International journal of artificial organs 2019-08, Vol.42 (8) |
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creator | Shimamura, J Mizuno, T Tsukiya, T Takewa, Y Inatomi, A Nishimura, T Ono, M Tatsumi, E |
description | We focused on the interventricular dyssynchrony caused by the shortened systole of left ventricle (LV) compared to right ventricle (RV) during left ventricular assist device (LVAD) support. The purpose of this study was to assess and quantify the mechanical interventricular dyssynchorny according to the support condition using conductance catheter. We studied five goats with normal heart condition. A centrifugal LVAD was implanted under general anesthesia. We inserted the conductance catheter into the LV and RV and obtained the pressure-volume relationship. We defined the dyssynchronous status by the sign (plus or minus) of the LV volume (LVV) change is opposite to that of RV volume (RVV). (i.e., (dLVV/dt)*(dRVV/dt) |
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The purpose of this study was to assess and quantify the mechanical interventricular dyssynchorny according to the support condition using conductance catheter. We studied five goats with normal heart condition. A centrifugal LVAD was implanted under general anesthesia. We inserted the conductance catheter into the LV and RV and obtained the pressure-volume relationship. We defined the dyssynchronous status by the sign (plus or minus) of the LV volume (LVV) change is opposite to that of RV volume (RVV). (i.e., (dLVV/dt)*(dRVV/dt)<0). Interventicular dyssynchrony (DYS) was quantified by calculating the percentage of time within the cardiac cycle. Bypass rate was set dividing the LVAD pump flow by the main pulmonary artery flow. We calculated the DYS under LVAD support with various bypass rate. The mean DYS of normal heart, LVAD clamp, LVAD support with bypass rate of 50%, 75 % and 100% were 6.0±1.3, 8.6±2.6, 9.6±1.8, 15.5±5.6, and 24.6±8.6, respectively. Also, there was a higher linear negative correlation between LV stroke volume and DYS. Interventricular dyssynchrony during LVAD support was assessed and quantified using conductance catheters. Dyssynchrony became significant when the LV was unloaded with high rotational speed under LVAD support. Assessment of influences for the right ventricular function and heart failure models will be studied in the further study.</description><identifier>ISSN: 0391-3988</identifier><identifier>EISSN: 1724-6040</identifier><language>eng</language><publisher>Milan: Wichtig Editore s.r.l</publisher><subject>Anesthesia ; Bypasses ; Catheters ; Conductance ; Congestive heart failure ; Goats ; Heart ; Heart rate ; Medical instruments ; Pulmonary arteries ; Pulmonary artery ; Resistance ; Stroke volume ; Systole ; Ventricle</subject><ispartof>International journal of artificial organs, 2019-08, Vol.42 (8)</ispartof><rights>Copyright Wichtig Editore s.r.l. Aug 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781</link.rule.ids></links><search><creatorcontrib>Shimamura, J</creatorcontrib><creatorcontrib>Mizuno, T</creatorcontrib><creatorcontrib>Tsukiya, T</creatorcontrib><creatorcontrib>Takewa, Y</creatorcontrib><creatorcontrib>Inatomi, A</creatorcontrib><creatorcontrib>Nishimura, T</creatorcontrib><creatorcontrib>Ono, M</creatorcontrib><creatorcontrib>Tatsumi, E</creatorcontrib><title>INTERVENTRICULAR DYSSYNCHRONY DURING CONTINUOUS-FLOW LEFT VENTRICULAR ASSIST DEVICE SUPPORT</title><title>International journal of artificial organs</title><description>We focused on the interventricular dyssynchrony caused by the shortened systole of left ventricle (LV) compared to right ventricle (RV) during left ventricular assist device (LVAD) support. The purpose of this study was to assess and quantify the mechanical interventricular dyssynchorny according to the support condition using conductance catheter. We studied five goats with normal heart condition. A centrifugal LVAD was implanted under general anesthesia. We inserted the conductance catheter into the LV and RV and obtained the pressure-volume relationship. We defined the dyssynchronous status by the sign (plus or minus) of the LV volume (LVV) change is opposite to that of RV volume (RVV). (i.e., (dLVV/dt)*(dRVV/dt)<0). Interventicular dyssynchrony (DYS) was quantified by calculating the percentage of time within the cardiac cycle. Bypass rate was set dividing the LVAD pump flow by the main pulmonary artery flow. We calculated the DYS under LVAD support with various bypass rate. The mean DYS of normal heart, LVAD clamp, LVAD support with bypass rate of 50%, 75 % and 100% were 6.0±1.3, 8.6±2.6, 9.6±1.8, 15.5±5.6, and 24.6±8.6, respectively. Also, there was a higher linear negative correlation between LV stroke volume and DYS. Interventricular dyssynchrony during LVAD support was assessed and quantified using conductance catheters. Dyssynchrony became significant when the LV was unloaded with high rotational speed under LVAD support. Assessment of influences for the right ventricular function and heart failure models will be studied in the further study.</description><subject>Anesthesia</subject><subject>Bypasses</subject><subject>Catheters</subject><subject>Conductance</subject><subject>Congestive heart failure</subject><subject>Goats</subject><subject>Heart</subject><subject>Heart rate</subject><subject>Medical instruments</subject><subject>Pulmonary arteries</subject><subject>Pulmonary artery</subject><subject>Resistance</subject><subject>Stroke volume</subject><subject>Systole</subject><subject>Ventricle</subject><issn>0391-3988</issn><issn>1724-6040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqNi7sOgjAAABujifj4hybOTQqU10hKkSakJX1giANxwIEYUZD_18HB0emGu1sAx408gkJM8BI42E9c5CdxvAabaeoxdkNCAgecuTBM1UwYxaktUwWzRutG0EJJ0cDMKi6OkEphuLDSapSX8gRLlhv4O6Vac21gxmpOGdS2qqQyO7C6Xm5Tt_9yCw45M7RAj3F4zt30avthHu8f1XpelMQYkyD2_6veaZE8kA</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Shimamura, J</creator><creator>Mizuno, T</creator><creator>Tsukiya, T</creator><creator>Takewa, Y</creator><creator>Inatomi, A</creator><creator>Nishimura, T</creator><creator>Ono, M</creator><creator>Tatsumi, E</creator><general>Wichtig Editore s.r.l</general><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope></search><sort><creationdate>20190801</creationdate><title>INTERVENTRICULAR DYSSYNCHRONY DURING CONTINUOUS-FLOW LEFT VENTRICULAR ASSIST DEVICE SUPPORT</title><author>Shimamura, J ; Mizuno, T ; Tsukiya, T ; Takewa, Y ; Inatomi, A ; Nishimura, T ; Ono, M ; Tatsumi, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_22798004583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Anesthesia</topic><topic>Bypasses</topic><topic>Catheters</topic><topic>Conductance</topic><topic>Congestive heart failure</topic><topic>Goats</topic><topic>Heart</topic><topic>Heart rate</topic><topic>Medical instruments</topic><topic>Pulmonary arteries</topic><topic>Pulmonary artery</topic><topic>Resistance</topic><topic>Stroke volume</topic><topic>Systole</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shimamura, J</creatorcontrib><creatorcontrib>Mizuno, T</creatorcontrib><creatorcontrib>Tsukiya, T</creatorcontrib><creatorcontrib>Takewa, Y</creatorcontrib><creatorcontrib>Inatomi, A</creatorcontrib><creatorcontrib>Nishimura, T</creatorcontrib><creatorcontrib>Ono, M</creatorcontrib><creatorcontrib>Tatsumi, E</creatorcontrib><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>International journal of artificial organs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shimamura, J</au><au>Mizuno, T</au><au>Tsukiya, T</au><au>Takewa, Y</au><au>Inatomi, A</au><au>Nishimura, T</au><au>Ono, M</au><au>Tatsumi, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>INTERVENTRICULAR DYSSYNCHRONY DURING CONTINUOUS-FLOW LEFT VENTRICULAR ASSIST DEVICE SUPPORT</atitle><jtitle>International journal of artificial organs</jtitle><date>2019-08-01</date><risdate>2019</risdate><volume>42</volume><issue>8</issue><issn>0391-3988</issn><eissn>1724-6040</eissn><abstract>We focused on the interventricular dyssynchrony caused by the shortened systole of left ventricle (LV) compared to right ventricle (RV) during left ventricular assist device (LVAD) support. The purpose of this study was to assess and quantify the mechanical interventricular dyssynchorny according to the support condition using conductance catheter. We studied five goats with normal heart condition. A centrifugal LVAD was implanted under general anesthesia. We inserted the conductance catheter into the LV and RV and obtained the pressure-volume relationship. We defined the dyssynchronous status by the sign (plus or minus) of the LV volume (LVV) change is opposite to that of RV volume (RVV). (i.e., (dLVV/dt)*(dRVV/dt)<0). Interventicular dyssynchrony (DYS) was quantified by calculating the percentage of time within the cardiac cycle. Bypass rate was set dividing the LVAD pump flow by the main pulmonary artery flow. We calculated the DYS under LVAD support with various bypass rate. The mean DYS of normal heart, LVAD clamp, LVAD support with bypass rate of 50%, 75 % and 100% were 6.0±1.3, 8.6±2.6, 9.6±1.8, 15.5±5.6, and 24.6±8.6, respectively. Also, there was a higher linear negative correlation between LV stroke volume and DYS. Interventricular dyssynchrony during LVAD support was assessed and quantified using conductance catheters. Dyssynchrony became significant when the LV was unloaded with high rotational speed under LVAD support. Assessment of influences for the right ventricular function and heart failure models will be studied in the further study.</abstract><cop>Milan</cop><pub>Wichtig Editore s.r.l</pub></addata></record> |
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subjects | Anesthesia Bypasses Catheters Conductance Congestive heart failure Goats Heart Heart rate Medical instruments Pulmonary arteries Pulmonary artery Resistance Stroke volume Systole Ventricle |
title | INTERVENTRICULAR DYSSYNCHRONY DURING CONTINUOUS-FLOW LEFT VENTRICULAR ASSIST DEVICE SUPPORT |
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