Frontispiece: Directing Traffic: Halogen‐Bond‐Mediated Membrane Transport

The efficient delivery of therapeutically active small molecules into mammalian cells is important for the development of new drugs. The transport of chemical compounds into cells is controlled by the plasma membrane, which consists of various receptors and transporters that mediate the intracellula...

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Bibliographic Details
Published in:Chemistry : a European journal 2019-08, Vol.25 (48), p.n/a
Main Authors: Govindaraj, Vijayakumar, Ungati, Harinarayana, Jakka, Surendar R., Bose, Sritama, Mugesh, Govindasamy
Format: Article
Language:English
Subjects:
Bioactive compounds
Biological activity
cellular uptake
Chemical compounds
Chemistry
Drug development
fluorescent molecules
halogen
Iodine
Mammalian cells
MCT8 transporter
Membrane trafficking
Organic chemistry
Pharmacology
Receptors
thyroid hormones
Traffic
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Summary:The efficient delivery of therapeutically active small molecules into mammalian cells is important for the development of new drugs. The transport of chemical compounds into cells is controlled by the plasma membrane, which consists of various receptors and transporters that mediate the intracellular delivery of biologically active compounds. The introduction of halogen, particularly iodine, atoms to small molecules and proteins is emerging as a novel and promising strategy not only for studying membrane activity and cellular functions, but also for improving the delivery of therapeutic agents. In their Concept article on page 11180 ff., Mugesh et. al. highlight halogen‐substitution as a novel strategy for understanding and regulating the cell‐membrane traffic.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201984861