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Lymphopenia as a Potential Predictor of Ipsilateral Breast Tumor Recurrence in Early Breast Cancer

The aim of this study was to investigate the association between lymphopenia after breast conserving therapy (BCT) and ipsilateral breast tumor recurrence (IBTR) in early breast cancer (EBC). We examined 216 EBC patients treated with partial mastectomy followed by radiotherapy (RT), none of whom rec...

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Published in:	Anticancer research 2019-08, Vol.39 (8), p.4467-4474
Main Authors:	Cho, Oyeon, Chun, Mison, Kim, Sang Won, Jung, Yong Sik, Yim, Hyunee
Format:	Article
Language:	English
Subjects:	Adult Aged Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - epidemiology Breast Neoplasms - pathology Breast Neoplasms - surgery Chemotherapy Combined Modality Therapy - adverse effects Disease-Free Survival Epidermal growth factor Female Growth factors Humans Lymphocyte Count Lymphocytes Lymphopenia Lymphopenia - chemically induced Lymphopenia - diagnosis Lymphopenia - epidemiology Lymphopenia - pathology Mastectomy Mastectomy, Segmental - adverse effects Middle Aged Multivariate analysis Neoplasm Recurrence, Local - diagnosis Radiation therapy Radiotherapy - adverse effects Radiotherapy, Adjuvant - adverse effects Tumors
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container_title	Anticancer research
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creator	Cho, Oyeon Chun, Mison Kim, Sang Won Jung, Yong Sik Yim, Hyunee
description	The aim of this study was to investigate the association between lymphopenia after breast conserving therapy (BCT) and ipsilateral breast tumor recurrence (IBTR) in early breast cancer (EBC). We examined 216 EBC patients treated with partial mastectomy followed by radiotherapy (RT), none of whom received chemotherapy. Absolute lymphocyte counts (ALCs) during the two years after RT were collected from each patient: pretreatment ALC, ALC at 3-5 months (ALC1), ALC at 9-11 months, ALC at 15-17 months, and ALC at 21-23 months. The 102 patients with ALC1 ≤1,479 cells/μl (defined as lymphopenia) had significantly higher 10-year IBTR rate than the 102 patients with ALC1 >1,479 cells/μl (16.2% vs. 1%, p=0.0034). The multivariate analysis showed that age, resection margins, human epidermal growth factor receptor, and lymphopenia were significant predictors of IBTR. Lymphopenia is a potential predictor for IBTR in EBC patients treated with BCT.
doi_str_mv	10.21873/anticanres.13620
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We examined 216 EBC patients treated with partial mastectomy followed by radiotherapy (RT), none of whom received chemotherapy. Absolute lymphocyte counts (ALCs) during the two years after RT were collected from each patient: pretreatment ALC, ALC at 3-5 months (ALC1), ALC at 9-11 months, ALC at 15-17 months, and ALC at 21-23 months. The 102 patients with ALC1 ≤1,479 cells/μl (defined as lymphopenia) had significantly higher 10-year IBTR rate than the 102 patients with ALC1 >1,479 cells/μl (16.2% vs. 1%, p=0.0034). The multivariate analysis showed that age, resection margins, human epidermal growth factor receptor, and lymphopenia were significant predictors of IBTR. Lymphopenia is a potential predictor for IBTR in EBC patients treated with BCT.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>DOI: 10.21873/anticanres.13620</identifier><identifier>PMID: 31366546</identifier><language>eng</language><publisher>Greece: International Institute of Anticancer Research</publisher><subject>Adult ; Aged ; Breast cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - epidemiology ; Breast Neoplasms - pathology ; Breast Neoplasms - surgery ; Chemotherapy ; Combined Modality Therapy - adverse effects ; Disease-Free Survival ; Epidermal growth factor ; Female ; Growth factors ; Humans ; Lymphocyte Count ; Lymphocytes ; Lymphopenia ; Lymphopenia - chemically induced ; Lymphopenia - diagnosis ; Lymphopenia - epidemiology ; Lymphopenia - pathology ; Mastectomy ; Mastectomy, Segmental - adverse effects ; Middle Aged ; Multivariate analysis ; Neoplasm Recurrence, Local - diagnosis ; Radiation therapy ; Radiotherapy - adverse effects ; Radiotherapy, Adjuvant - adverse effects ; Tumors</subject><ispartof>Anticancer research, 2019-08, Vol.39 (8), p.4467-4474</ispartof><rights>Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.</rights><rights>Copyright International Institute of Anticancer Research Aug 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-5fc371455ee8276f59574f8b7fb8f80f7a9dc190d361dcea53f132cdd5c307d93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31366546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cho, Oyeon</creatorcontrib><creatorcontrib>Chun, Mison</creatorcontrib><creatorcontrib>Kim, Sang Won</creatorcontrib><creatorcontrib>Jung, Yong Sik</creatorcontrib><creatorcontrib>Yim, Hyunee</creatorcontrib><title>Lymphopenia as a Potential Predictor of Ipsilateral Breast Tumor Recurrence in Early Breast Cancer</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>The aim of this study was to investigate the association between lymphopenia after breast conserving therapy (BCT) and ipsilateral breast tumor recurrence (IBTR) in early breast cancer (EBC). 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subjects	Adult Aged Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - epidemiology Breast Neoplasms - pathology Breast Neoplasms - surgery Chemotherapy Combined Modality Therapy - adverse effects Disease-Free Survival Epidermal growth factor Female Growth factors Humans Lymphocyte Count Lymphocytes Lymphopenia Lymphopenia - chemically induced Lymphopenia - diagnosis Lymphopenia - epidemiology Lymphopenia - pathology Mastectomy Mastectomy, Segmental - adverse effects Middle Aged Multivariate analysis Neoplasm Recurrence, Local - diagnosis Radiation therapy Radiotherapy - adverse effects Radiotherapy, Adjuvant - adverse effects Tumors
title	Lymphopenia as a Potential Predictor of Ipsilateral Breast Tumor Recurrence in Early Breast Cancer
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