Expression of Matrix Metalloproteinases in Intraductal Papillary Mucinous Neoplasm of the Pancreas

• Published in: Anticancer research 2019-08, Vol.39 (8), p.4485-4490
• Main Authors: Akashi, Masanori, Hisaka, Toru, Sakai, Hisamune, Ishikawa, Hiroto, Kawahara, Ryuichi, Goto, Yuichi, Nomura, Yoriko, Yasunaga, Masafumi, Fujita, Fumihiko, Tanigawa, Masahiko, Naito, Yoshiki, Akiba, Jun, Yano, Hirohisa, Tanaka, Hiroyuki, Akagi, Yoshito, Okuda, Koji
• Format: Article
• Language: English
• Subjects: Correlation analysis; Interstitial collagenase; Lesions; Matrix metalloproteinase; Matrix metalloproteinases; Pancreas; Pancreatic cancer; Prognosis; Staining; Tumors
• ISSN: 0250-7005; 1791-7530
• DOI: 10.21873/anticanres.13623

Intraductal papillary mucinous neoplasm (IPMN) has a variety of histological and morphological appearances. Matrix metalloproteinases (MMPs) have been considered to be associated with tumor progression or poor prognosis. The aim of this study was to elucidate the molecular basis of IPMN variation in different types of lesions. The expression of MMP-1,2,7,9 in 51 cases of IPMN were investigated. The MMP score was calculated as the sum of the score of staining distribution and the score of the intensity staining. MMP scores were correlated with histological grade, histological subtype, and type of invasion. MMP high expression groups (MMP score ≥5) had worse prognosis than low-expression groups. MMP expression varied between different types of IPMN, a result supporting differences in molecular basis of malignancies. These considerations may be helpful for optimal management or treatment according to various types of IPMN.