Species-specific models in toxicology: in vitro epithelial barriers

Species-specific in vitro epithelial barriers represent interesting predictive tools for risk assessment evaluation in toxicological studies. Moreover, these models could be applied either as stand-alone methods for the study of absorption, bioavailability, excretion, transport, effects of xenobioti...

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2019-08, Vol.70, p.103203, Article 103203
Main Authors: Bertero, A., Augustyniak, J., Buzanska, L., Caloni, F.
Format: Article
Language:English
Subjects:
Animals
Barriers
Bioavailability
Blood-Brain Barrier
Brain
Epithelium
Evaluation
Excretion
Female
Humans
in vitro
Intestine
Intestines
Livestock
Lung
Mammary Glands, Animal - metabolism
Models, Biological
Risk assessment
Skin
Species
Species Specificity
Species-specific
Swine
Toxicants
Toxicity testing
Toxicology
Xenobiotics
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Summary:Species-specific in vitro epithelial barriers represent interesting predictive tools for risk assessment evaluation in toxicological studies. Moreover, these models could be applied either as stand-alone methods for the study of absorption, bioavailability, excretion, transport, effects of xenobiotics, or through an Integrated Testing Strategy. The aim of this review is to give a comprehensive overview of in vitro species-specific epithelial barrier models from bovine, dog and swine. Bovine mammary epithelial barrier as a fundamental instrument for the evaluation of the toxicant excretion, the blood brain barrier as a useful first approach in toxicological and pharmacological studies, the porcine intestinal barrier, the canine skin barrier, and finally the pulmonary barrier from bovine and swine species are described in this review.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2019.103203