Invasive Group A Streptococcal Infection and Nonsteroidal Antiinflammatory Drug Use Among Children With Primary Varicella

To test the hypothesis that nonsteroidal antiinflammatory drug use increases the risk of necrotizing soft tissue infections and, secondarily, all invasive group A streptococcal (GAS) infections in children with primary varicella infection. We conducted a prospective, multicenter case-control study a...

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Bibliographic Details
Published in:Pediatrics (Evanston) 2001-05, Vol.107 (5), p.1108-1115
Main Authors: Lesko, Samuel M, O'Brien, Katherine L, Schwartz, Benjamin, Vezina, Richard, Mitchell, Allen A
Format: Article
Language:English
Subjects:
Acetaminophen - adverse effects
Adolescent
Analgesics, Non-Narcotic - adverse effects
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Bacterial diseases
Biological and medical sciences
Case-Control Studies
Chickenpox - complications
Child
Child, Preschool
Children & youth
Complications and side effects
Fasciitis, Necrotizing - etiology
Female
Fever - drug therapy
Fever - etiology
Health care
Human bacterial diseases
Human viral diseases
Humans
Ibuprofen
Ibuprofen - adverse effects
Infant
Infections
Infectious diseases
Logistic Models
Male
Medical sciences
Multivariate Analysis
Nonsteroidal anti-inflammatory agents
Nonsteroidal anti-inflammatory drugs
Pediatrics
Pharmaceuticals
Prospective Studies
Risk
Risk factors
Staphylococcal infections, streptococcal infections, pneumococcal infections
Steroids
Streptococcal infections
Streptococcal Infections - etiology
Streptococcus pyogenes
Viral diseases
Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
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Description
Summary:To test the hypothesis that nonsteroidal antiinflammatory drug use increases the risk of necrotizing soft tissue infections and, secondarily, all invasive group A streptococcal (GAS) infections in children with primary varicella infection. We conducted a prospective, multicenter case-control study among children
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.107.5.1108