A Multicenter Randomized Masked Comparison Trial of Synthetic Surfactant Versus Calf Lung Surfactant Extract in the Prevention of Neonatal Respiratory Distress Syndrome

To compare the efficacy and safety of a synthetic surfactant (Exosurf Neonatal, Burroughs Wellcome Co) and a surfactant extract of calf lung lavage (Infasurf, IND #27,169, ONY, Inc) in the prevention of neonatal respiratory distress syndrome (RDS). Ten-center randomized masked comparison trial. Prem...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1997-07, Vol.100 (1), p.39-50
Main Authors: Hudak, Mark L, Martin, David J, Egan, Edmund A, Matteson, Elizabeth J, Cummings, J, Jung, August L, Kimberlin, Lois V, Auten, Richard L, Rosenberg, Adam A, Asselin, Jeanette M, Belcastro, Marc R, Donohue, Pamela K, Hamm Jr, Charles R, Jansen, Robert D, Brody, Alan S, Riddlesberger, Merchline M, Montgomery, Paul
Format: Article
Language:English
Subjects:
Age Factors
Babies
Biological and medical sciences
Bronchopulmonary Dysplasia - prevention & control
Care and treatment
Cerebral Hemorrhage - prevention & control
Data Interpretation, Statistical
Drug Combinations
Evaluation
Fatty Alcohols - administration & dosage
Fatty Alcohols - adverse effects
Fatty Alcohols - therapeutic use
Female
Humans
Infant, Newborn
Linear Models
Lung surfactant, Synthetic
Lungs
Male
Medical research
Medical sciences
Pediatrics
Pharmacology. Drug treatments
Phosphorylcholine
Polyethylene Glycols - administration & dosage
Polyethylene Glycols - adverse effects
Polyethylene Glycols - therapeutic use
Pulmonary Surfactants - administration & dosage
Pulmonary Surfactants - adverse effects
Pulmonary Surfactants - therapeutic use
Respiratory diseases
Respiratory distress syndrome
Respiratory Distress Syndrome, Newborn - mortality
Respiratory Distress Syndrome, Newborn - prevention & control
Respiratory system
Synthetic lung surfactants
Time Factors
Treatment Outcome
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Summary:To compare the efficacy and safety of a synthetic surfactant (Exosurf Neonatal, Burroughs Wellcome Co) and a surfactant extract of calf lung lavage (Infasurf, IND #27,169, ONY, Inc) in the prevention of neonatal respiratory distress syndrome (RDS). Ten-center randomized masked comparison trial. Premature infants (n = 871)
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.100.1.39