pH‐Responsive Starch‐Citrate Nanoparticles for Controlled Release of Paracetamol

Starch‐citrate samples with degrees of substitution (DS) ranging from 0.11 to 0.90 are synthesized by a green esterification reaction between citric acid and native sago starch (Metroxylon sagu) in an aqueous medium. Starch‐citrate nanoparticles with mean diameter of 105 nm are subsequently obtained...

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Bibliographic Details
Published in:Starch - Stärke 2019-09, Vol.71 (9-10), p.n/a
Main Authors: Chin, Suk Fun, Romainor, Ain N. B., Pang, Suh Cem, Lee, Boon Kiat, Hwang, Siaw San
Format: Article
Language:English
Subjects:
Analgesics
Aqueous solutions
Biocompatibility
Biomedical materials
Cell lines
Chemical precipitation
Citric acid
Controlled release
Cytotoxicity
Drug carriers
Drug delivery
drug release profiles
Esterification
Ethanol
Kinetics
Nanoparticles
Paracetamol
pH effects
pH‐responsive
Reaction kinetics
Skin
Starch
starch‐citrate nanoparticles
Substitution reactions
Toxicity
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Summary:Starch‐citrate samples with degrees of substitution (DS) ranging from 0.11 to 0.90 are synthesized by a green esterification reaction between citric acid and native sago starch (Metroxylon sagu) in an aqueous medium. Starch‐citrate nanoparticles with mean diameter of 105 nm are subsequently obtained by controlled precipitation through drop‐wise addition of dissolved starch‐citrate solution into excess absolute ethanol. These nanoparticles are observed to exhibit pH‐responsive release profiles within the physiological pH range of 1.2–8.6. The release profile of a model drug (paracetamol) is observed to obey the zero‐order kinetics, with the release mechanism based on the diffusion and swelling model. The cytotoxicity study in HaCaT cell lines (human skin cells) shows that starch‐citrate nanoparticles are non‐toxic and hence are suitable for biomedical applications as pH‐responsive drug carriers. pH responsive starch‐citrate nanoparticles are prepared. The nanoparticles can be used to control the release of drugs such as paracetamol.
ISSN:0038-9056
1521-379X
DOI:10.1002/star.201800336