Fatal hantavirus pulmonary syndrome in an adolescent

Hantavirus pulmonary syndrome (HPS) is a recently recognized viral zoonosis characterized by a febrile prodrome progressing to severe noncardiogenic pulmonary edema.1-4 This syndrome is caused by at least three newly described hantaviruses: the first, Sin Nombre virus, is the Southwestern hantavirus...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1995-02, Vol.95 (2), p.276-280
Main Authors: KHAN, A. S, KZIAZEK, T. G, KUKLINSKI, D, ZAKI, S. R. NICHOL S. T, ROLLIN, P. E, PETERS, C. J, KHABBAZ, R. F, CHEEK, J. E, SHIRELEY, L. A, MCDONOUGH, S. L, WELTY, T. K
Format: Article
Language:English
Subjects:
Adolescent
Animals
Arvicolinae - virology
Biological and medical sciences
Camping
Case studies
Diseases
Enzyme-Linked Immunosorbent Assay
Fatal Outcome
Hantavirus - isolation & purification
Hantavirus infections
Hantavirus Pulmonary Syndrome - diagnosis
Hantavirus Pulmonary Syndrome - epidemiology
Hantavirus Pulmonary Syndrome - transmission
Human viral diseases
Humans
Infectious diseases
Lungs
Male
Medical disorders
Medical sciences
North Dakota - epidemiology
Pediatrics
Peromyscus - virology
Polymerase Chain Reaction
South Dakota
Teenagers
Viral diseases
Viral diseases of the respiratory system and ent viral diseases
Viruses
Youth
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Description
Summary:Hantavirus pulmonary syndrome (HPS) is a recently recognized viral zoonosis characterized by a febrile prodrome progressing to severe noncardiogenic pulmonary edema.1-4 This syndrome is caused by at least three newly described hantaviruses: the first, Sin Nombre virus, is the Southwestern hantavirus that caused an outbreak of respiratory failure during the summer of 1993; the second, Black Creek Canal virus, caused a case of HPS in Florida; and the third hantavirus was identified in lung tissue from a patient in Louisiana. Diagnosis is by enzyme-linked immunosorbent assay (ELISA) serology with elevated immunoglobulin M (IgM) titers against heterologous and homologous hantaviral antigens, positive immunohistochemistry on formalin-fixed tissue, or reverse transcriptase-polymerase chain reaction (RT-PCR) amplification of hantaviral nucleotide sequence from frozen tissue.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.95.2.276