Modeling the Effect of Mucin Binding in the Gut on Drug Delivery

An important part the absorption, distribution, metabolism and excretion of an oral therapeutic is the flux rate of drug compound crossing the mucus lining of the gut. To understand this part of the absorption process, we develop a mathematical model of advection, diffusion and binding of drug compo...

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Bibliographic Details
Published in:Bulletin of mathematical biology 2019-09, Vol.81 (9), p.3460-3476
Main Authors: Saltzman, Jeffrey, Bendtsen, Claus
Format: Article
Language:English
Subjects:
Absorption
Animals
Applied mathematics
Binding
Cell Biology
Computer Simulation
Diffusion layers
Drug delivery
Drug delivery systems
Drug Delivery Systems - methods
Drug Delivery Systems - statistics & numerical data
Drug Development - methods
Drug Development - statistics & numerical data
Excretion
Humans
Intestinal Absorption
Intestinal Mucosa - metabolism
Intestine
Life Sciences
Mathematical and Computational Biology
Mathematical Concepts
Mathematical models
Mathematics
Mathematics and Statistics
Metabolism
Models, Biological
Mucin
Mucins - metabolism
Mucus
Nonlinear Dynamics
Pharmaceutical Preparations - administration & dosage
Pharmacokinetics
Protein Binding
Proteins
Special Issue: Mathematics to Support Drug Discovery and Development
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Summary:An important part the absorption, distribution, metabolism and excretion of an oral therapeutic is the flux rate of drug compound crossing the mucus lining of the gut. To understand this part of the absorption process, we develop a mathematical model of advection, diffusion and binding of drug compounds within the mucus layer of the intestines. Analysis of this model yields simple, measurable criteria for the successful mucin layer traversal of drug compound.
ISSN:0092-8240
1522-9602
DOI:10.1007/s11538-018-0417-3