Phosphorylated STAT 3 expression predicts better prognosis in smoldering type of adult T‐cell leukemia/lymphoma

Adult T‐cell leukemia/lymphoma ( ATLL ) is a mature T‐cell neoplasm, and is divided into 2 indolent (smoldering and chronic) and 2 aggressive (acute and lymphoma) clinical subtypes. Based on previous integrated molecular analyses suggesting the importance of the JAK‐ STAT pathway in ATLL , we attemp...

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Bibliographic Details
Published in:Cancer science 2019-09, Vol.110 (9), p.2982-2991
Main Authors: Morichika, Kazuho, Karube, Kennosuke, Kayo, Hirona, Uchino, Shuta, Nishi, Yukiko, Nakachi, Sawako, Okamoto, Shiki, Morishima, Satoko, Ohshiro, Kazuiku, Nakazato, Iwao, Fukushima, Takuya, Masuzaki, Hiroaki
Format: Article
Language:English
Subjects:
Cancer
Cell cycle
Children & youth
Classification
Cloning
Gene expression
Homology
Immunohistochemistry
Leukemia
Lymphoma
Medical prognosis
Morphology
Multivariate analysis
Mutation
Pathogenesis
Prognosis
Stat3 protein
Tumor cells
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Summary:Adult T‐cell leukemia/lymphoma ( ATLL ) is a mature T‐cell neoplasm, and is divided into 2 indolent (smoldering and chronic) and 2 aggressive (acute and lymphoma) clinical subtypes. Based on previous integrated molecular analyses suggesting the importance of the JAK‐ STAT pathway in ATLL , we attempted to clarify the clinicopathological significance of this pathway. Clinical and morphological findings were reviewed in 116 cases with ATLL . The nuclear localizations of phosphorylated STAT 3 ( pSTAT 3), pSTAT 5, and pSTAT 6 were analyzed by immunohistochemistry. Targeted sequencing was undertaken on the portion of STAT 3 encoding the Src homology 2 domain. Expression of pSTAT 3 was observed in 43% (50/116) of ATLL cases, whereas pSTAT 5 and pSTAT 6 were largely undetected. Cases with the lymphoma type showed significantly less frequent pSTAT 3 expression (8/45, 18%) than those with the other subtypes (41/66, 62%; P 
ISSN:1347-9032
1349-7006
DOI:10.1111/cas.14114