Simultaneous Determination of Dipyridamole and Acetylsalicylic Acid in Pharmaceuticals and Biological Fluids by Synchronous and First Derivative Synchronous Fluorimetry

[...]order derivative spectrophometric [14], spectrofluorometric [15] and electrochemical methods [16]. When Д X is more than 80 nm, poor separation of the two peaks was obtained. [...]Д X of 80 nm was chosen as the optimal one for the separation of the mixture of DPR with ASA, since it resulted in...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences and research 2019-08, Vol.11 (8), p.2949-2955
Main Authors: Fahelelbom, Khairi M S, El-Shabrawy, Yasser
Format: Article
Language:English
Subjects:
Acids
Angina pectoris
Aspirin
Blood platelets
Calibration
Chromatography
Drug dosages
Mass spectrometry
Methods
Pharmaceuticals
Scientific imaging
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Summary:[...]order derivative spectrophometric [14], spectrofluorometric [15] and electrochemical methods [16]. When Д X is more than 80 nm, poor separation of the two peaks was obtained. [...]Д X of 80 nm was chosen as the optimal one for the separation of the mixture of DPR with ASA, since it resulted in two distinct peaks with good shape and to minimize the spectral interference caused by each compound in the mixture Figures(3-9). The output of the read head is differentiated to reproduce the data signal as recorded on the magnetic medium [20]. [...]Figure 8 shows zero crossing synchronous fluorimetry of binary mixture 60 ng / ml DPR and 40 ng/ml ASA, respectively, the produced data signal for both figures is compared with a reference signal representing the zero level of the data signal so as to produce a bi-level signal which changes level upon the occurrence of each zero crossing, so no interferences between the two signals, hence so, the method proved to be highly selective. [...]the method is highly sensitive, since, the detection limits were determined as (S/N = 3) were found to be 0.05 ngml-1 for both dipyridamole and acetylsalicylic acid.
ISSN:0975-1459