Digital Beings as an option to study gut flora evolution and adaptation

In this work, we introduce a computational model for the study of the host-bacteria interaction and the influence of the intestinal microbiota on the behavior and feeding pattern of an individual. The model is based on digital entities, which we've called Digital Beings (DBs), modeled using dyn...

Full description

Saved in:
Bibliographic Details
Published in:arXiv.org 2019-09
Main Authors: João Paulo Almeida de Mendonça, Leonardo da Motta de Vasconcellos Teixeira, Sato, Fernando
Format: Article
Language:English
Subjects:
Bacteria
Biological evolution
Biomedical materials
Genetic algorithms
In vivo methods and tests
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this work, we introduce a computational model for the study of the host-bacteria interaction and the influence of the intestinal microbiota on the behavior and feeding pattern of an individual. The model is based on digital entities, which we've called Digital Beings (DBs), modeled using dynamic systems and genetic algorithms. We have successfully tested the use of the DBs by reproducing observation in previously made studies using rats and humans. Among these studies, we highlight those on how the bacteria in an individual's stomach could influence their eating behavior and how a controlled and continuous diet can affect the longevity of a certain population. Our results point that the Digital Beings can be used as a tool for supporting the devising of experiments and corroborating with theoretical hypotheses, reducing the number of in vivo tests.
ISSN:2331-8422