P04 Trends in incidence of ischaemic stroke in people with and without diabetes in ireland 2005–2015

BackgroundStroke is a leading cause of neurological disability and mortality worldwide1. Diabetes is a risk factor for stroke, conferring up to four times the risk2. We aimed to estimate trends in incidence of ischaemic stroke (IS) and in-hospital mortality (IHM) associated with IS among people with...

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Published in:Journal of epidemiology and community health (1979) 2019-09, Vol.73 (Suppl 1), p.A74
Main Authors: Bambury, N, O’Neill, K, Buckley, CM, Kearney, PM
Format: Article
Language:English
Subjects:
Diabetes
Diabetes mellitus
Females
Health promotion
Health risk assessment
Ischemia
Males
Mortality
Neurological complications
Public health
Regression analysis
Risk factors
Risk groups
Stroke
Trends
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creator Bambury, N
O’Neill, K
Buckley, CM
Kearney, PM
description BackgroundStroke is a leading cause of neurological disability and mortality worldwide1. Diabetes is a risk factor for stroke, conferring up to four times the risk2. We aimed to estimate trends in incidence of ischaemic stroke (IS) and in-hospital mortality (IHM) associated with IS among people with and without diabetes in Ireland from 2005 to 2015.MethodsData were extracted from the national Hospital Inpatient Enquiry (HIPE) database. Incidence rates (IR) and IHM rates in people with and without diabetes were calculated. Poisson regression models, adjusted for age, were used to calculate the incidence rate ratio (IRR) and trends over time.ResultsIn males with diabetes there was an average decrease in IR of 1.7% per year (IRR 0.983 (95% CI 0.974–0.991), p
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Diabetes is a risk factor for stroke, conferring up to four times the risk2. We aimed to estimate trends in incidence of ischaemic stroke (IS) and in-hospital mortality (IHM) associated with IS among people with and without diabetes in Ireland from 2005 to 2015.MethodsData were extracted from the national Hospital Inpatient Enquiry (HIPE) database. Incidence rates (IR) and IHM rates in people with and without diabetes were calculated. Poisson regression models, adjusted for age, were used to calculate the incidence rate ratio (IRR) and trends over time.ResultsIn males with diabetes there was an average decrease in IR of 1.7% per year (IRR 0.983 (95% CI 0.974–0.991), p<0.001) over the 11 years. In males without diabetes, the IR remained unchanged (IRR 0.998 (95% CI 0.994–1.00), p<0.25). In females, there was an average decrease in IR of 3.3% per year in those with diabetes (IRR 0.967 (95% CI 0.957- 0.976), p<0.001) and 1% per year in those without diabetes (IRR 0.99 (95% CI 0.985–0.994, p<0.001).The IRR for the association between diabetes and IS was 2.0 (95% CI 1.95–2.06), p<0.001) for males and 2.2 (95% CI 2.12–2.27), p<0.001) for females over the study period. The IRR of IHM is higher in males (IRR 1.81 (1.67–1.97) and females (IRR 2.0 (95% CI 1.84–2.18) with diabetes compared to those without diabetes. Over the 11-years, 8.2% of incident cases were attributable to diabetes.ConclusionThis study provides evidence of the significant contribution of diabetes to IS incidence and mortality in Ireland. Estimates of national trends are necessary to deliver public health interventions targeted at high risk groups.ReferencesWorld Health Organization. The World Bank World Report on Disability. Geneva: WHO; 2011.Khoury JC, Kleindorfer D, Alwell K, Moomaw CJ, Woo D, Adeoye O, et al. Diabetes mellitus: a risk factor for ischemic stroke in a large biracial population. Stroke. 2013;44(6):1500–4.]]></description><identifier>ISSN: 0143-005X</identifier><identifier>EISSN: 1470-2738</identifier><identifier>DOI: 10.1136/jech-2019-SSMabstracts.156</identifier><language>eng</language><publisher>London: BMJ Publishing Group LTD</publisher><subject>Diabetes ; Diabetes mellitus ; Females ; Health promotion ; Health risk assessment ; Ischemia ; Males ; Mortality ; Neurological complications ; Public health ; Regression analysis ; Risk factors ; Risk groups ; Stroke ; Trends</subject><ispartof>Journal of epidemiology and community health (1979), 2019-09, Vol.73 (Suppl 1), p.A74</ispartof><rights>2019, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>2019 2019, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jech.bmj.com/content/73/Suppl_1/A74.1.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://jech.bmj.com/content/73/Suppl_1/A74.1.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>112,113,314,780,784,27924,27925,77466,77467</link.rule.ids></links><search><creatorcontrib>Bambury, N</creatorcontrib><creatorcontrib>O’Neill, K</creatorcontrib><creatorcontrib>Buckley, CM</creatorcontrib><creatorcontrib>Kearney, PM</creatorcontrib><title>P04 Trends in incidence of ischaemic stroke in people with and without diabetes in ireland 2005–2015</title><title>Journal of epidemiology and community health (1979)</title><description><![CDATA[BackgroundStroke is a leading cause of neurological disability and mortality worldwide1. Diabetes is a risk factor for stroke, conferring up to four times the risk2. We aimed to estimate trends in incidence of ischaemic stroke (IS) and in-hospital mortality (IHM) associated with IS among people with and without diabetes in Ireland from 2005 to 2015.MethodsData were extracted from the national Hospital Inpatient Enquiry (HIPE) database. Incidence rates (IR) and IHM rates in people with and without diabetes were calculated. Poisson regression models, adjusted for age, were used to calculate the incidence rate ratio (IRR) and trends over time.ResultsIn males with diabetes there was an average decrease in IR of 1.7% per year (IRR 0.983 (95% CI 0.974–0.991), p<0.001) over the 11 years. In males without diabetes, the IR remained unchanged (IRR 0.998 (95% CI 0.994–1.00), p<0.25). In females, there was an average decrease in IR of 3.3% per year in those with diabetes (IRR 0.967 (95% CI 0.957- 0.976), p<0.001) and 1% per year in those without diabetes (IRR 0.99 (95% CI 0.985–0.994, p<0.001).The IRR for the association between diabetes and IS was 2.0 (95% CI 1.95–2.06), p<0.001) for males and 2.2 (95% CI 2.12–2.27), p<0.001) for females over the study period. The IRR of IHM is higher in males (IRR 1.81 (1.67–1.97) and females (IRR 2.0 (95% CI 1.84–2.18) with diabetes compared to those without diabetes. Over the 11-years, 8.2% of incident cases were attributable to diabetes.ConclusionThis study provides evidence of the significant contribution of diabetes to IS incidence and mortality in Ireland. Estimates of national trends are necessary to deliver public health interventions targeted at high risk groups.ReferencesWorld Health Organization. The World Bank World Report on Disability. Geneva: WHO; 2011.Khoury JC, Kleindorfer D, Alwell K, Moomaw CJ, Woo D, Adeoye O, et al. Diabetes mellitus: a risk factor for ischemic stroke in a large biracial population. Stroke. 2013;44(6):1500–4.]]></description><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Females</subject><subject>Health promotion</subject><subject>Health risk assessment</subject><subject>Ischemia</subject><subject>Males</subject><subject>Mortality</subject><subject>Neurological complications</subject><subject>Public health</subject><subject>Regression analysis</subject><subject>Risk factors</subject><subject>Risk groups</subject><subject>Stroke</subject><subject>Trends</subject><issn>0143-005X</issn><issn>1470-2738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpNkMFKAzEQhoMoWKvvsOh5a5JNNslRilqhotAK3kI2mbJZ2911s0W89eIT-IZ9ErPWgzAwA_Pz_zMfQpcETwjJ8usKbJlSTFS6WDyaIvSdsX2YEJ4foRFhAqdUZPIYjTBhWYoxfz1FZyFUOI6CqhEqnzHb776WHdQuJL6OZb2D2kLSrBIfbGlg420SnZs3GAQtNO0akg_fl4mp3e_QbPvEeVNADweTDtbDjsaY_e47HsjP0cnKrANc_PUxerm7XU5n6fzp_mF6M08LQvM8pSoDlnNXFMAsNQ7iE0IwY5UwBBvFMmuNyIniCnOHuSwozQ1xUkmAlWTZGF0dfNuued9C6HXVbLs6RmpKpRSccCKjih9UxabSbec3pvvUBOsBqh6g6gGq_g9VR6jZDyc5b-k</recordid><startdate>201909</startdate><enddate>201909</enddate><creator>Bambury, N</creator><creator>O’Neill, K</creator><creator>Buckley, CM</creator><creator>Kearney, PM</creator><general>BMJ Publishing Group LTD</general><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>201909</creationdate><title>P04 Trends in incidence of ischaemic stroke in people with and without diabetes in ireland 2005–2015</title><author>Bambury, N ; 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Diabetes is a risk factor for stroke, conferring up to four times the risk2. We aimed to estimate trends in incidence of ischaemic stroke (IS) and in-hospital mortality (IHM) associated with IS among people with and without diabetes in Ireland from 2005 to 2015.MethodsData were extracted from the national Hospital Inpatient Enquiry (HIPE) database. Incidence rates (IR) and IHM rates in people with and without diabetes were calculated. Poisson regression models, adjusted for age, were used to calculate the incidence rate ratio (IRR) and trends over time.ResultsIn males with diabetes there was an average decrease in IR of 1.7% per year (IRR 0.983 (95% CI 0.974–0.991), p<0.001) over the 11 years. In males without diabetes, the IR remained unchanged (IRR 0.998 (95% CI 0.994–1.00), p<0.25). In females, there was an average decrease in IR of 3.3% per year in those with diabetes (IRR 0.967 (95% CI 0.957- 0.976), p<0.001) and 1% per year in those without diabetes (IRR 0.99 (95% CI 0.985–0.994, p<0.001).The IRR for the association between diabetes and IS was 2.0 (95% CI 1.95–2.06), p<0.001) for males and 2.2 (95% CI 2.12–2.27), p<0.001) for females over the study period. The IRR of IHM is higher in males (IRR 1.81 (1.67–1.97) and females (IRR 2.0 (95% CI 1.84–2.18) with diabetes compared to those without diabetes. Over the 11-years, 8.2% of incident cases were attributable to diabetes.ConclusionThis study provides evidence of the significant contribution of diabetes to IS incidence and mortality in Ireland. Estimates of national trends are necessary to deliver public health interventions targeted at high risk groups.ReferencesWorld Health Organization. The World Bank World Report on Disability. Geneva: WHO; 2011.Khoury JC, Kleindorfer D, Alwell K, Moomaw CJ, Woo D, Adeoye O, et al. Diabetes mellitus: a risk factor for ischemic stroke in a large biracial population. Stroke. 2013;44(6):1500–4.]]></abstract><cop>London</cop><pub>BMJ Publishing Group LTD</pub><doi>10.1136/jech-2019-SSMabstracts.156</doi><oa>free_for_read</oa></addata></record>
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source JSTOR Archival Journals and Primary Sources Collection; BMJ Journals
subjects Diabetes
Diabetes mellitus
Females
Health promotion
Health risk assessment
Ischemia
Males
Mortality
Neurological complications
Public health
Regression analysis
Risk factors
Risk groups
Stroke
Trends
title P04 Trends in incidence of ischaemic stroke in people with and without diabetes in ireland 2005–2015
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