Low serum level of high‐sensitivity C ‐reactive protein in a J apanese patient with maturity‐onset diabetes of the young type 3 (MODY3)

High‐sensitivity C‐reactive protein (hs‐ CRP ) levels in E uropean populations are lower in patients with maturity‐onset diabetes of the young type 3 ( MODY 3) than in those with type 2 diabetes. hs‐ CRP levels have been suggested to be useful for discriminating MODY 3 from type 2 diabetes. As hs‐ C...

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Published in:Journal of diabetes investigation 2014-09, Vol.5 (5), p.513-516
Main Authors: Ohki, Tsuyoshi, Utsu, Yoshihiko, Morita, Shinya, Karim, Md. Fazlul, Sato, Yoshifumi, Yoshizawa, Tatsuya, Yamamura, Ken‐ichi, Yamada, Kentaro, Kasayama, Soji, Yamagata, Kazuya
Format: Article
Language:English
Subjects:
Age
Binding sites
Biomarkers
Body mass index
Cholesterol
Deoxyribonucleic acid
Diabetes
Diabetes mellitus
Diabetes mellitus (insulin dependent)
Diabetes mellitus (non-insulin dependent)
Diabetic retinopathy
DNA
Gene expression
Hemoglobin
HNF1a gene
Insulin
Liver
Mutation
Nonsense mutation
Patients
Polymerase chain reaction
Proteins
Standardization
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Summary:High‐sensitivity C‐reactive protein (hs‐ CRP ) levels in E uropean populations are lower in patients with maturity‐onset diabetes of the young type 3 ( MODY 3) than in those with type 2 diabetes. hs‐ CRP levels have been suggested to be useful for discriminating MODY 3 from type 2 diabetes. As hs‐ CRP levels are influenced by various factors including race and body mass index, it is worthwhile to examine whether hs‐ CRP can serve as a biomarker for MODY 3 in Japanese. Here we describe the case of a Japanese MODY 3 patient with a nonsense mutation in the HNF 1A gene. Two measurements showed consistently lower hs‐ CRP levels (
ISSN:2040-1116
2040-1124
DOI:10.1111/jdi.12237