Silencing of STRN 4 suppresses the malignant characteristics of cancer cells

The striatin family of proteins, comprising STRN , STRN 3 and STRN 4, are multidomain‐containing proteins that associate with additional proteins to form a large protein complex. We previously reported that STRN 4 directly associated with protein kinases, such as MINK 1, TNIK and MAP 4K4, which are...

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Bibliographic Details
Published in:Cancer science 2014-12, Vol.105 (12), p.1526-1532
Main Authors: Wong, Meihong, Hyodo, Toshinori, Asano, Eri, Funasaka, Kohei, Miyahara, Ryoji, Hirooka, Yoshiki, Goto, Hidemi, Hamaguchi, Michinari, Senga, Takeshi
Format: Article
Language:English
Subjects:
Cell adhesion & migration
Cell division
Cell growth
Cell proliferation
Colorectal cancer
Experiments
Gemcitabine
Insects
Kinases
Malignancy
Metastases
Pancreatic cancer
Phosphatase
Pore size
Protein kinase
Proteins
Tumor suppression
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Summary:The striatin family of proteins, comprising STRN , STRN 3 and STRN 4, are multidomain‐containing proteins that associate with additional proteins to form a large protein complex. We previously reported that STRN 4 directly associated with protein kinases, such as MINK 1, TNIK and MAP 4K4, which are associated with tumor suppression or tumor progression. However, it remains unclear whether STRN 4 is associated with tumor progression. In this report, we examined the role that STRN 4 plays in cancer malignancy. We show that depletion of STRN 4 suppresses proliferation, migration, invasion and the anchorage‐independent growth of cancer cells. In addition, STRN 4 knockdown increases the sensitivity of pancreatic cancer cells to gemcitabine. Finally, we show that STRN 4 knockdown suppresses the proliferation and metastasis of cancer cells in mice. Our results demonstrate a possible role of STRN 4 in tumor progression.
ISSN:1347-9032
1349-7006
DOI:10.1111/cas.12541