Prostaglandin D 2 metabolites as a biomarker of in vivo mast cell activation in systemic mastocytosis and rheumatoid arthritis

Mast cells (MCs) participate in diseases such as systemic mastocytosis (SM) and allergic conditions. Less well understood is the role of MCs in non‐allergic inflammatory disorders like rheumatoid arthritis (RA). Studying definitive roles for MCs in human diseases has been hampered by the lack of a w...

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Bibliographic Details
Published in:Immunity, Inflammation and Disease Inflammation and Disease, 2016-03, Vol.4 (1), p.64-69
Main Authors: Cho, Catherine, Nguyen, Anna, Bryant, Katherine J., O'Neill, Sean G., McNeil, H. Patrick
Format: Article
Language:English
Subjects:
Anaphylaxis
Asthma
Autoimmune diseases
Biomarkers
Inflammation
Metabolites
Patients
Rheumatoid arthritis
Studies
Urine
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Summary:Mast cells (MCs) participate in diseases such as systemic mastocytosis (SM) and allergic conditions. Less well understood is the role of MCs in non‐allergic inflammatory disorders like rheumatoid arthritis (RA). Studying definitive roles for MCs in human diseases has been hampered by the lack of a well‐accepted biomarker for monitoring in vivo MC activation. This study aimed to investigate the utility of urinary tetranor PGDM (T‐PGDM) as a biomarker of in vivo MC activation in patients with SM, and apply this biomarker to assess MC involvement in relation to RA disease activity. A prospective, cross‐sectional cohort study was conducted to measure a major urinary metabolite of prostaglandin D2, T‐PGDM. Urine samples were collected from patients with RA (n = 60), SM (n = 17) and healthy normal controls (n = 16) and T‐PGDM excretion was determined by enzyme immunoassay as nanograms per milligram of urinary creatinine (ng/mg Cr). Mean urinary T‐PGDM excretion was significantly higher (p 
ISSN:2050-4527
2050-4527
DOI:10.1002/iid3.94