The Barrett‐associated variants at GDF 7 and TBX 5 also increase esophageal adenocarcinoma risk

Barrett's esophagus ( BE ) and esophageal adenocarcinoma ( EAC ) represent two stages within the esophagitis‐metaplasia‐dysplasia‐adenocarcinoma sequence. Previously genetic risk factors have been identified that confer risk to BE and EAC development. However, to which extent the genetic varian...

Full description

Saved in:
Bibliographic Details
Published in:Cancer medicine (Malden, MA) MA), 2016-05, Vol.5 (5), p.888-891
Main Authors: Becker, Jessica, May, Andrea, Gerges, Christian, Anders, Mario, Schmidt, Claudia, Veits, Lothar, Noder, Tania, Mayershofer, Rupert, Kreuser, Nicole, Manner, Hendrik, Venerito, Marino, Hofer, Jan‐Hinnerk, Lyros, Orestis, Ahlbrand, Constantin J., Arras, Michael, Hofer, Sebastian, Heinrichs, Sophie K. M., Weise, Katharina, Hess, Timo, Böhmer, Anne C., Kosiol, Nils, Kiesslich, Ralf, Izbicki, Jakob R., Hölscher, Arnulf H., Bollschweiler, Elfriede, Malfertheiner, Peter, Lang, Hauke, Moehler, Markus, Lorenz, Dietmar, Ott, Katja, Schmidt, Thomas, Nöthen, Markus M., Hackelsberger, Andreas, Schumacher, Brigitte, Pech, Oliver, Vashist, Yogesh, Vieth, Michael, Weismüller, Josef, Knapp, Michael, Neuhaus, Horst, Rösch, Thomas, Ell, Christian, Gockel, Ines, Schumacher, Johannes
Format: Article
Language:English
Subjects:
Adenocarcinoma
Alcohol
Barrett's esophagus
Chromosomes
Disease
Dysplasia
Esophageal cancer
Esophagitis
Esophagus
Gastroesophageal reflux
Genes
Genetic diversity
Genomes
Metaplasia
Population
Quality control
Risk factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Barrett's esophagus ( BE ) and esophageal adenocarcinoma ( EAC ) represent two stages within the esophagitis‐metaplasia‐dysplasia‐adenocarcinoma sequence. Previously genetic risk factors have been identified that confer risk to BE and EAC development. However, to which extent the genetic variants confer risk to different stages of the BE / EAC sequence remains mainly unknown. In this study we analyzed three most recently identified BE variants at the genes GDF 7 (rs3072), TBX 5 (rs2701108), and ALDH 1A2 (rs3784262) separately in BE and EAC samples in order to determine their risk effects during BE / EAC sequence. Our data show that rs3072 at GDF 7 and rs2701108 at TBX 5 are also associated with EAC and conclude that both loci confer disease risk also at later stages of the BE / EAC sequence. In contrast, rs3784262 at ALDH 1A2 was highly significantly associated with BE , but showed no association with EAC . Our data do not provide evidence that the ALDH 1A2 locus confers equal risk in early and late stages of BE / EAC sequence.
ISSN:2045-7634
2045-7634
DOI:10.1002/cam4.641