Chemical constituents of Kopsia officinalis and their antagonizing high glucose-evoked podocyte injury activity

Four new indole alkaloids (1–4) and twenty known compounds (5–24) were isolated from the leaves and stems, and fruits of Kopsia officinalis. Their structures were confirmed by means of spectroscopic methods. All these isolates were evaluated for their antagonizing high glucose-evoked podocyte injury...

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Bibliographic Details
Published in:Fitoterapia 2019-09, Vol.137, p.104258, Article 104258
Main Authors: Wang, Zhi-Wei, Guo, Chang-Run, Lin, Yun-Liang, Yan, Hui-Jiao, Mu, Yan, Geng, Yan-Ling, Liu, Wei, Wang, Xiao
Format: Article
Language:English
Subjects:
Alkaloids
Diabetic nephropathy
Glucose
Indole alkaloid
Indoles
Kopsia officinalis
Organic chemistry
Podocyte injury
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Summary:Four new indole alkaloids (1–4) and twenty known compounds (5–24) were isolated from the leaves and stems, and fruits of Kopsia officinalis. Their structures were confirmed by means of spectroscopic methods. All these isolates were evaluated for their antagonizing high glucose-evoked podocyte injury activity for the first time, and compounds 5–8 showed potent activity with EC50 values of 3.0–12.0 μM. [Display omitted]
ISSN:0367-326X
1873-6971
DOI:10.1016/j.fitote.2019.104258