Neuroprotective effect of catechins derivatives isolated from Anhua dark tea on NMDA-induced excitotoxicity in SH-SY5Y cells

Anhua dark tea known as the earliest produced Chinese dark tea, has been commercially available and famous for its unique flavor and health care effect. NMDA receptors are glutamate-coupled ion channels that critically involved in survival of neuronal cells and neurodegenerative diseases. Thus, it i...

Full description

Saved in:
Bibliographic Details
Published in:Fitoterapia 2019-09, Vol.137, p.104240, Article 104240
Main Authors: Liu, Jianyu, Fan, Yanhua, Kim, Donghwa, Zhong, Ting, Yi, Ping, Fan, Chengcheng, Wang, Andong, Yang, Xiaosheng, Lee, Sangkook, Ren, Xuhong, Xu, Yongnan
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
AKT protein
Anhua dark tea
Apoptosis
Bioassays
Brain injury
Caspase
Catechin
Catechin derivatives
Derivatives
Diet
Excitotoxicity
Flavonoids
Flavor
Glutamic acid receptors (ionotropic)
Head injuries
Injury prevention
Ion channels
N-Methyl-D-aspartic acid receptors
Neurodegenerative diseases
Neurological diseases
Neuroprotection
Neuroprotective effects
NMDA receptors
Reagents
Receptors
Tea
Therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Anhua dark tea known as the earliest produced Chinese dark tea, has been commercially available and famous for its unique flavor and health care effect. NMDA receptors are glutamate-coupled ion channels that critically involved in survival of neuronal cells and neurodegenerative diseases. Thus, it is considered a promising target for the therapy of neurodegenerative disease. In this study, four catechins including two new catechins derivatives (1–2), together with thirteen known flavonoids were isolated from Anhua dark tea. The structures of compounds 1–2 [2S,3R-6-methoxycarbonylgallocatechin (1) and 2R,3R-6-methoxycarbonylgallocatechin (2)] were determined on the basis of their spectroscopic data. The preliminary bioassay indicated that compound 1 showed the best neuroprotective effects via N-methyl-d-aspartate (NMDA) receptors inhibition. Compound 1 protected SH-SY5Y cells against NMDA-induced injury and cell apoptosis via the modulation of NR2B expression, the activation of PI3K/Akt signaling and caspase-dependent pathway. The results suggested compound 1 would be a potent dietary therapy reagent for prevention of excitable brain injury. [Display omitted]
ISSN:0367-326X
1873-6971
DOI:10.1016/j.fitote.2019.104240