Tobacco smoking-associated genome-wide DNA methylation changes in the EPIC study

: Epigenetic changes may occur in response to environmental stressors, and an altered epigenome pattern may represent a stable signature of environmental exposure. Here, we examined the potential of DNA methylation changes in 910 prediagnostic peripheral blood samples as a marker of exposure to toba...

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Bibliographic Details
Published in:Epigenomics 2016-05, Vol.8 (5), p.599-618
Main Authors: Ambatipudi, Srikant, Cuenin, Cyrille, Hernandez-Vargas, Hector, Ghantous, Akram, Le Calvez-Kelm, Florence, Kaaks, Rudolf, Barrdahl, Myrto, Boeing, Heiner, Aleksandrova, Krasimira, Trichopoulou, Antonia, Lagiou, Pagona, Naska, Androniki, Palli, Domenico, Krogh, Vittorio, Polidoro, Silvia, Tumino, Rosario, Panico, Salvatore, Bueno-de-Mesquita, Bas, Peeters, Petra HM, Quirós, José Ramón, Navarro, Carmen, Ardanaz, Eva, Dorronsoro, Miren, Key, Tim, Vineis, Paolo, Murphy, Neil, Riboli, Elio, Romieu, Isabelle, Herceg, Zdenko
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers
Cancer
Cigarette smoking
CpG Islands
Deoxyribonucleic acid
DNA
DNA Methylation
DNA methylome
Drug addiction
Epigenesis, Genetic
epigenetic signature
Epigenetics
Female
Genes
Genomes
Genomics
Humans
Male
Middle Aged
Peripheral blood
Phosphatase
prospective cohort
Prospective Studies
Sequence Analysis, DNA
Smoke
Smoking
Smoking Cessation
Studies
Tobacco
Tobacco smoking
Tobacco Smoking - genetics
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Summary:: Epigenetic changes may occur in response to environmental stressors, and an altered epigenome pattern may represent a stable signature of environmental exposure. Here, we examined the potential of DNA methylation changes in 910 prediagnostic peripheral blood samples as a marker of exposure to tobacco smoke in a large multinational cohort. : We identified 748 CpG sites that were differentially methylated between smokers and nonsmokers, among which we identified novel regionally clustered CpGs associated with active smoking. Importantly, we found a marked reversibility of methylation changes after smoking cessation, although specific genes remained differentially methylated up to 22 years after cessation. : Our study has comprehensively cataloged the smoking-associated DNA methylation alterations and showed that these alterations are reversible after smoking cessation.
ISSN:1750-1911
1750-192X
DOI:10.2217/epi-2016-0001