Synthesis, Spectral Characterization and Antibacterial Activity of Functionalized Hydrazones

New hydrazones have been synthesized by condensing 2-acetylthiophene with acetic hydrazide and benzhydrazide. The synthesized hydrazones viz. 2-acetylthiophene acetoylhydrazone (ATAH), 2-acetylthiophene benzoylhydrazone (ATBH) are characterized in the light of physicochemical and analytical data. St...

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Bibliographic Details
Published in:Oriental journal of chemistry 2019-01, Vol.35 (2), p.557-562
Main Authors: Kasimbi, D., Reddy, K.Hussain, Devanna, N.
Format: Article
Language:English
Subjects:
Cancer
Conflicts of interest
E coli
Ethanol
Hydrazones
Microorganisms
NMR
Nuclear magnetic resonance
Synthesis
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Summary:New hydrazones have been synthesized by condensing 2-acetylthiophene with acetic hydrazide and benzhydrazide. The synthesized hydrazones viz. 2-acetylthiophene acetoylhydrazone (ATAH), 2-acetylthiophene benzoylhydrazone (ATBH) are characterized in the light of physicochemical and analytical data. Structures of ATAH and ATBH are confirmed by FT-IR, 1H-NMR and Mass spectral data. The hydrazones are screened for their anti-bacterial activities against E Coli, Bacillus cereus, Staphylococcus aureus and Pseudomonas aureoginos. Acetoyl hydrazones are found to show more antibacterial activity than the corresponding benzoyl hydrazones.
ISSN:0970-020X
2231-5039
DOI:10.13005/ojc/350208