Nonlinear relationship between triglyceride/high-density lipoprotein cholesterol ratio and chronic kidney disease in US adults: a National Health and Nutrition Examination Survey investigation

Purpose Published data on the association between triglycerides/high-density lipoprotein cholesterol (TG/HDL-C) ratio and chronic kidney disease (CKD) in US populations are limited. We examined the association between TG/HDL-C ratio and the prevalence of CKD using US National Health and Nutrition Ex...

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Bibliographic Details
Published in:International urology and nephrology 2019-11, Vol.51 (11), p.2005-2014
Main Authors: Yu, Le, Zhou, Limin, Zhou, Di, Hu, Guiping
Format: Article
Language:English
Subjects:
Adult
Aged
Cholesterol
Cholesterol, HDL - blood
Cross-Sectional Studies
Epidermal growth factor receptors
Female
Glomerular filtration rate
High density lipoprotein
Humans
Kidney diseases
Male
Medicine
Medicine & Public Health
Middle Aged
Nephrology
Nephrology - Original Paper
Nonlinear systems
Nutrition Surveys
Prevalence
Regression analysis
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - epidemiology
Triglycerides
Triglycerides - blood
United States
Urology
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Summary:Purpose Published data on the association between triglycerides/high-density lipoprotein cholesterol (TG/HDL-C) ratio and chronic kidney disease (CKD) in US populations are limited. We examined the association between TG/HDL-C ratio and the prevalence of CKD using US National Health and Nutrition Examination Survey (NHANES) database. Methods This cross-sectional study included 13,780 US adults from NHANES (1999–2006). CKD was defined as an estimated glomerular filtration rate (eGFR)  0.05). Conclusions Our study suggested saturated effects of TG/HDL-C ratio on the prevalence of CKD among US adults. TG/HDL-C ratio less than 6.68 was positively and independently associated with CKD.
ISSN:0301-1623
1573-2584
DOI:10.1007/s11255-019-02287-y