Thyroid hormones induce unique and potentially beneficial changes in cardiac myocyte shape in hypertensive rats near heart failure

We examined the effects of thyroid hormones (THs) on left ventricular (LV) function and myocyte remodeling in rats with spontaneously hypertensive heart failure (SHHF). SHHF rats were treated with three different TH doses from 20-21 mo of age. In terminal experiments, LV function (as determined by e...

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Published in:American journal of physiology. Heart and circulatory physiology 2005-05, Vol.57 (5), p.H2118-H2122
Main Authors: THOMAS, Tracy A, KUZMAN, James A, ANDERSON, Brent E, ANDERSEN, Susan M. K, SCHLENKER, Evelyn H, HOLDER, Maurice S, GERDES, A. Martin
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cells
Changes
Fundamental and applied biological sciences. Psychology
Heart failure
Hormones
Hypertension
Rodents
Thyroid gland
Vertebrates: cardiovascular system
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Summary:We examined the effects of thyroid hormones (THs) on left ventricular (LV) function and myocyte remodeling in rats with spontaneously hypertensive heart failure (SHHF). SHHF rats were treated with three different TH doses from 20-21 mo of age. In terminal experiments, LV function (as determined by echocardiography and catheterization) and isolated myocyte shape were examined in SHHF rat groups and age-matched Wistar-Furth control animals. Compared with Wistar-Furth rats, the ratio of {alpha}- to {beta}-myosin was reduced in untreated SHHF rats. The {alpha}-to-{beta}-myosin ratio increased in all TH groups, which suggests a reversal of the fetal gene program. Low-dose TH produced no changes in LV myocyte size or function, but high-dose TH produced signs of hyperthyroidism (e.g., increased heart weight, tachycardia). The chamber diameter-to-wall thickness ratio declined with increasing dose due to reduced chamber diameter and increased wall thickness. This resulted in a 38% reduction in LV systolic wall stress in the middle- and high-dose groups despite sustained hypertension. Isolated myocyte data indicated that chamber remodeling and reduced wall stress were due to a unique alteration in myocyte transverse shape (e.g., reduced major diameter and increased minor diameter). Based on our present understanding of ventricular remodeling and wall stress, we believe these changes are likely beneficial. Results suggest that TH may be an important regulator of myocyte transverse shape in heart disease. [PUBLICATION ABSTRACT]
ISSN:0363-6135
1522-1539