Inhibition of nitric oxide synthesis increases venular permeability and alters endothelial actin cytoskeleton

Inhibition of nitric oxide (NO) synthesis using NG-nitro-L-arginine methyl ester(L-NAME) or NG-monomethyl-L-arginine (L-NMMA) increases venular permeability in the rat mesentery (I. Kurose, R. Wolf, M. B. Grisham, T. Y. Aw, R D. Specian, and D. N. Granger. Circ. Res. 76: 30-39, 1995), but the cellul...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 1998-05, Vol.43 (5), p.H1776-H1784
Main Authors: BALDWIN, A. L, THURSTON, G, AL NAEMI, H
Format: Article
Language:English
Subjects:
Anatomy & physiology
Biological and medical sciences
Blood vessels and receptors
Circulatory system
Fundamental and applied biological sciences. Psychology
Rodents
Vertebrates: cardiovascular system
Online Access:Get full text
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Summary:Inhibition of nitric oxide (NO) synthesis using NG-nitro-L-arginine methyl ester(L-NAME) or NG-monomethyl-L-arginine (L-NMMA) increases venular permeability in the rat mesentery (I. Kurose, R. Wolf, M. B. Grisham, T. Y. Aw, R D. Specian, and D. N. Granger. Circ. Res. 76: 30-39, 1995), but the cellular mechanisms of this response are not known. This study was performed to determine whether such venular leaks are associated with changes in the endothelial actin cytoskeleton.
ISSN:0363-6135
1522-1539