Identification of ecto-PKC on surface of human platelets : role in maintenance of latent fibrinogen receptors

Human platelets express a protein phosphorylation system on their surface. A specific protein kinase C (PKC) antibody, monoclonal antibody (MAb) 1.9, which binds to the catalytic domain of PKC and inhibits its activity, causes the aggregation of intact platelets while inhibiting the phosphorylation...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 2000-06, Vol.47 (6), p.H2008-H2019
Main Authors: BABINSKA, A, HOGAN, M. V, SOBOCKI, T, SOBOCKA, M. B, EHRLICH, Y. H, KORNECKI, E
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood coagulation. Blood cells
Cellular biology
Fundamental and applied biological sciences. Psychology
Molecular and cellular biology
Platelet
Proteins
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Summary:Human platelets express a protein phosphorylation system on their surface. A specific protein kinase C (PKC) antibody, monoclonal antibody (MAb) 1.9, which binds to the catalytic domain of PKC and inhibits its activity, causes the aggregation of intact platelets while inhibiting the phosphorylation of platelet surface proteins.
ISSN:0363-6135
1522-1539