Mechanisms by which bradykinin promotes fibrosis in vascular smooth muscle cells : role of TGF-β and MAPK

Accumulation of extracellular matrix (ECM) is a hallmark feature of vascular disease. We have previously shown that hyperglycemia induces the expression of B2-kinin receptors in vascular smooth muscle cells (VSMC) and that bradykinin (BK) and hyperglycemia synergize to stimulate ECM production.

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 2000-12, Vol.48 (6), p.H2829-H2837
Main Authors: DOUILLET, Christelle D, VELARDE, Victoria, CHRISTOPHER, Julie T, MAYFIELD, Ronald K, TROJANOWSKA, Maria E, JAFFA, Ayad A
Format: Article
Language:English
Subjects:
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Blood vessels
Cardiology. Vascular system
Cells
Circulatory system
Medical sciences
Muscular system
Proteins
Tissues
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Description
Summary:Accumulation of extracellular matrix (ECM) is a hallmark feature of vascular disease. We have previously shown that hyperglycemia induces the expression of B2-kinin receptors in vascular smooth muscle cells (VSMC) and that bradykinin (BK) and hyperglycemia synergize to stimulate ECM production.
ISSN:0363-6135
1522-1539