Progesterone regulation of vascular thromboxane A2 receptors in rhesus monkeys

We hypothesized that progesterone regulates thromboxane A2 receptor (TxA2R) density in primate vascular muscle and that TxA2R density correlates with coronary reactivity in vivo and in vitro. Reactivity to serotonin + U-46619 was determined by angiography in surgically post-menopausal [lovariectomiz...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 2001-10, Vol.50 (4), p.H1498-H1507
Main Authors: MINSHALL, Richard D, PAVCNIK, Dusan, HALUSHKA, Perry V, HERMSMEYER, Kent
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiovascular disease
Hormones
Hormones. Endocrine system
Medical sciences
Menopause
Monkeys & apes
Pharmacology. Drug treatments
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Summary:We hypothesized that progesterone regulates thromboxane A2 receptor (TxA2R) density in primate vascular muscle and that TxA2R density correlates with coronary reactivity in vivo and in vitro. Reactivity to serotonin + U-46619 was determined by angiography in surgically post-menopausal [lovariectomized (Ovx)] rhesus monkeys without progesterone replacement and after 2-wk progesterone treatment (1-2 ng/ml).
ISSN:0363-6135
1522-1539