PKC-dependent activation of p44/p42 MAPKs during myocardial ischemia-reperfusion in conscious rabbits

Using conscious rabbits, we examined the effect of ischemic preconditioning (PC) on p44 and p42 mitogen-activated protein kinases (MAPKs). We found that both isoforms contribute significantly to total MAPK activity in the heart (in-gel kinase assay: p44, 59 +/- 1%; p42, 41 +/- 1%).

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 1999-05, Vol.45 (5), p.H1468-H1481
Main Authors: PEIPEI PING, JUN ZHANG, BOLLI, R, XINAN CAO, LI, R. C. X, DEYING KONG, TANG, X.-L, YUMIN QIU, MANCHIKALAPUDI, S, AUCHAMPACH, J. A, BLACK, R. G
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiology
Cardiology. Vascular system
Cellular biology
Coronary heart disease
Heart
Medical sciences
Proteins
Rabbits
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Summary:Using conscious rabbits, we examined the effect of ischemic preconditioning (PC) on p44 and p42 mitogen-activated protein kinases (MAPKs). We found that both isoforms contribute significantly to total MAPK activity in the heart (in-gel kinase assay: p44, 59 +/- 1%; p42, 41 +/- 1%).
ISSN:0363-6135
1522-1539