Nitric oxide-endothelin-1 interactions after acute ductal constriction in fetal lambs

Acute partial compression of the fetal ductus arteriosus (DA) results in an initial increase in pulmonary blood flow (PBF) that is followe by acute vasoconstriction. The objective of the present study was to determine the role of nitric oxide (NO)-endothelin-1 (ET-1) insteractions in the acute chang...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 2002-03, Vol.51 (3), p.862-871
Main Authors: OVADIA, Boaz, BEKKER, Janine M, FITZGERALD, Robert K, KON, Alexander, THELITZ, Stephan, JOHENGEN, Michael J, HENDRICKS-MUNOZ, Karen, GERRETS, Rene, BLACK, Stephen M, FINEMAN, Jeffrey R
Format: Article
Language:English
Subjects:
Air breathing
Biological and medical sciences
Circulatory system
Fetuses
Fundamental and applied biological sciences. Psychology
Lungs
Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics
Sheep
Vertebrates: respiratory system
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Summary:Acute partial compression of the fetal ductus arteriosus (DA) results in an initial increase in pulmonary blood flow (PBF) that is followe by acute vasoconstriction. The objective of the present study was to determine the role of nitric oxide (NO)-endothelin-1 (ET-1) insteractions in the acute changes in pulmonary vascular tone after in utero partial constriction of the DA.
ISSN:0363-6135
1522-1539