Long-term effects of nonpeptide vasopressin V2 antagonist OPC-31260 in heart failure in the rat

The hormone arginine vasopressin (AVP) contributes to water retention and vasoconstriction in congestive heart failure (CHF) through effects at the V2 and V1a receptors, respectively. The effect of long-term V2 receptor (V2R) blockade using OPC-31260 was assessed in a rat model of postinfarction-ind...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 1998-07, Vol.44 (1), p.H176-H182
Main Authors: BURRELL, L. M, PHILLIPS, P. A, RISVANIS, J, CHAN, R. K, ALDRED, K. L, JOHNSTON, C. I
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiology
Cardiovascular system
Heart failure
Hormones
Medical sciences
Miscellaneous
Pharmacology. Drug treatments
Rodents
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Summary:The hormone arginine vasopressin (AVP) contributes to water retention and vasoconstriction in congestive heart failure (CHF) through effects at the V2 and V1a receptors, respectively. The effect of long-term V2 receptor (V2R) blockade using OPC-31260 was assessed in a rat model of postinfarction-induced CHF.
ISSN:0363-6135
1522-1539