Melatonin as an effective protector against doxorubicin-induced cardiotoxicity

Liu et al explored the protective effects of melatonin and its analogs, 6-hydroxymelatonin and 8-methoxy-2-propionamidotetralin, on the survival of doxorubicin-treated mice and on doxorubicin-induced cardiac dysfunction, ultrastructural alterations, and apoptosis in mouse hearts.

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 2002-07, Vol.52 (1), p.H254-H263
Main Authors: XUWAN LIU, ZHONGYI CHEN, CHU CHANG CHUA, MA, Yan-Shan, YOUNGBERG, George A, HAMDY, Ronald, CHUA, Balvin H. L
Format: Article
Language:English
Subjects:
Antibiotics
Biological and medical sciences
Cells
Drug toxicity and drugs side effects treatment
Heart
Hormones
Medical sciences
Pharmacology. Drug treatments
Rodents
Toxicity
Toxicity: cardiovascular system
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Summary:Liu et al explored the protective effects of melatonin and its analogs, 6-hydroxymelatonin and 8-methoxy-2-propionamidotetralin, on the survival of doxorubicin-treated mice and on doxorubicin-induced cardiac dysfunction, ultrastructural alterations, and apoptosis in mouse hearts.
ISSN:0363-6135
1522-1539